Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | DNMT3B | Q9UBC3 | 7/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9166328 | 0.84 | ALDH1A1 (0.35) | ALDH1A1LMNAAGTR1NPC1MAOB | |
| SCHEMBL9303669 | 0.81 | CA2 (0.35) | RAB9AALDH1A1LMNACYP2C9CYP2C19 | |
| SCHEMBL9174733 | 0.79 | ALDH1A1 (0.40) | PTGS2ALDH1A1LMNAKMT2A | |
| SCHEMBL9172583 | 0.77 | PARP1 (0.43) | RAB9ACYP1B1KDM4ENPC1MAPT | |
| SCHEMBL8576377 | 0.77 | KDM4E (0.40) | RAB9AALDH1A1CYP1B1KDM4ENPC1 | |
| SCHEMBL8574206 | 0.75 | HPGD (0.46) | RAB9AALDH1A1NPC1MAOBKMT2A | |
| SCHEMBL8796640 | 0.74 | RAB9A (0.44) | RAB9AALDH1A1LMNACYP2C9CYP2C19 | |
| SCHEMBL9184179 | 0.73 | L3MBTL1 (0.52) | RAB9AALDH1A1LMNACYP2C9CYP2C19 | |
| Sinitrodil SCHEMBL31066546 | 0.72 | TSHR (0.34) | RAB9APTGS2ALDH1A1LMNAAGTR1 | |
| Sinitrodil SCHEMBL503115 | 0.72 | TSHR (0.34) | RAB9APTGS2ALDH1A1LMNAAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490183-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1995-04-19 | — | — | EP | disclosed |
| US-5189034-A | Vasodilating, antianginal agents | ITALFARMACO S.P.A. (IT) | 1993-02-23 | — | — | US | disclosed |
| EP-0490183-A1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1992-06-17 | — | — | EP | disclosed |