Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8980633 | 0.84 | HEXA (0.38) | TSHRKDM4EALOX15SIRT1MAPK1 | |
| SCHEMBL6144233 | 0.79 | ALDH1A1 (0.49) | — | |
| SCHEMBL9166362 | 0.76 | MMP2 (0.34) | TSHRKDM4EALOX15SIRT1MAPK1 | |
| SCHEMBL5636228 | 0.71 | KDM4E (0.64) | TSHRKDM4EALOX15SIRT1ACHE | |
| SCHEMBL7683501 | 0.69 | DRD3 (0.56) | ACHE | |
| SCHEMBL30513123 | 0.68 | NPC1 (0.51) | KDM4EBCHECES1HTT | |
| SCHEMBL8639215 | 0.68 | TSHR (0.41) | TSHRKDM4EALOX15SIRT1MAOB | |
| SCHEMBL2296434 | 0.65 | GLS (0.61) | KDM4EGLSHTT | |
| SCHEMBL29750183 | 0.65 | GLS (0.61) | KDM4EGLSHTT | |
| SCHEMBL9635018 | 0.65 | NOTUM (0.42) | KDM4EALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490183-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1995-04-19 | — | — | EP | disclosed |
| US-5189034-A | Vasodilating, antianginal agents | ITALFARMACO S.P.A. (IT) | 1993-02-23 | — | — | US | disclosed |
| EP-0490183-A1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1992-06-17 | — | — | EP | disclosed |