Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | MAOB | P27338 | 1/20 | 0.68 |
| ▸ | CACNA2D1 | P54289 | 6/20 | 0.67 |
| ▸ | CACNA1B | Q00975 | 6/20 | 0.67 |
| ▸ | CACNB1 | Q02641 | 6/20 | 0.67 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.64 |
| ▸ | MGLL | Q99685 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.59 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27545187 | 0.85 | KMT2A (0.74) | KMT2AMAOBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL917195 | 0.84 | GPX4 (0.69) | CACNA2D1CACNA1BCACNB1CACNA1CMGLL | |
| SCHEMBL917471 | 0.83 | CACNA2D1 (0.59) | KMT2ACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL13994872 | 0.82 | KMT2A (1.00) | KMT2AMAOBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL5624203 | 0.82 | KMT2A (0.70) | KMT2AMAOBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL3301602 | 0.81 | GPX4 (0.75) | KMT2AMAOBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL3397269 | 0.81 | ALDH1A1 (0.72) | KMT2AMAOBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL31350986 | 0.81 | MAOB (1.00) | KMT2AMAOBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL8175607 | 0.80 | OPRM1 (0.78) | KMT2AMAOBCACNA2D1CACNA1BCACNB1 | |
| SCHEMBL3396540 | 0.80 | CACNA2D1 (1.00) | KMT2AMAOBCACNA2D1CACNA1BCACNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071161-A1 | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-03-24 | — | — | US | disclosed |
| US-7868007-B2 | Triazolopyridine carboxamide derivatives, preparation thereof and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2011-01-11 | — | — | US | disclosed |
| US-20100035893-A1 | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035893-A1 | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | FLT3, QDPR, CYP1A2 | KMT2A 951/4885MAOB 60/4885CACNA2D1 489/4885 |
| US-20110071161-A1 | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | FLT3, QDPR, CYP1A2 | KMT2A 951/4885MAOB 60/4885CACNA2D1 489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.