Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9081767 | 0.75 | HDAC1 (0.40) | FDPSHDAC1HDAC6RXFP1DNMT3B | |
| SCHEMBL11543167 | 0.73 | FDPS (0.42) | FDPSHDAC1HDAC6DNMT3BSMN1; SMN2 | |
| SCHEMBL7592031 | 0.71 | FDPS (0.40) | FDPSHDAC1HDAC6DNMT3BALOX15 | |
| SCHEMBL21977344 | 0.70 | CYP1A2 (0.51) | RXFP1ALOX15SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL21977345 | 0.70 | CYP1A2 (0.51) | RXFP1ALOX15SMN1; SMN2ALDH1A1CYP1A2 | |
| SCHEMBL28172599 | 0.67 | FDPS (0.41) | FDPSHDAC1HDAC6DNMT3BALDH1A1 | |
| SCHEMBL27535766 | 0.66 | FDPS (0.40) | FDPSHDAC1HDAC6DNMT3BALDH1A1 | |
| SCHEMBL1371020 | 0.66 | FDPS (0.40) | FDPSHDAC1HDAC6ALOX15SMN1; SMN2 | |
| SCHEMBL1831228 | 0.65 | USP5 (0.48) | FDPSHDAC1HDAC6DNMT3BKDM4E | |
| SCHEMBL2563784 | 0.65 | FDPS (0.38) | FDPSHDAC1HDAC6ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426467-B1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RES FOUND (US) | 1995-04-05 | — | — | EP | disclosed |
| US-5120740-A | PRODRUGS OF 6-MERCAPTOPURINE AND 6-THIOGUANINE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0426467-A1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-05-08 | — | — | EP | disclosed |