Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303871 | 0.83 | OPRM1 (0.42) | OPRM1OPRD1OPRK1DRD2CCR3 | |
| SCHEMBL8303188 | 0.83 | HTR2B (0.33) | DRD3DRD4DRD2CCR3HTR1A | |
| SCHEMBL8303444 | 0.82 | SIGMAR1 (0.55) | POLBDRD2CCR3 | |
| SCHEMBL9143193 | 0.80 | DRD2 (0.39) | DRD3DRD4DRD2CCR3HTR1A | |
| SCHEMBL8303201 | 0.80 | SIGMAR1 (0.43) | OPRM1OPRD1OPRK1POLBDRD2 | |
| SCHEMBL8307036 | 0.79 | HRH3 (0.51) | DRD4CCR3HRH3HTR1ASLC6A2 | |
| SCHEMBL8303556 | 0.79 | SIGMAR1 (0.43) | OPRM1OPRD1OPRK1DRD2CCR3 | |
| SCHEMBL8304291 | 0.78 | SIGMAR1 (0.46) | DRD4HTR1ASLC6A4ADRA1A | |
| SCHEMBL9178363 | 0.76 | SIGMAR1 (0.41) | DRD3DRD4DRD2CCR3HTR1A | |
| SCHEMBL8306497 | 0.76 | SIGMAR1 (0.42) | OPRM1OPRD1OPRK1CCR3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | disclosed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | disclosed |