SCHEMBL917916

SCHEMBL917916

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(NC(=O)c5ccccc5)ncnc43)[C@H](OC(=O)Nc3ccccc3)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PRMT6 Q96LA8 1/20 0.41
▸ TYMP P19971 2/20 0.41
▸ P2RY12 Q9H244 4/20 0.38
▸ PRKAG1 P54619 2/20 0.36
▸ PRKAA1 Q13131 2/20 0.36
▸ PRKAB1 Q9Y478 2/20 0.36
▸ PRKAB2 O43741 1/20 0.36
▸ PRKAA2 P54646 1/20 0.36
▸ PRKAG3 Q9UGI9 1/20 0.36
▸ PRKAG2 Q9UGJ0 1/20 0.36
▸ P2RY2 P41231 1/20 0.36
▸ P2RY1 P47900 1/20 0.36
▸ P2RY6 Q15077 1/20 0.36
▸ DOT1L Q8TEK3 1/20 0.36
▸ BMPR1B O00238 1/20 0.35
▸ ADORA1 P30542 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24878603 0.94 TYMP (0.43) PRMT6TYMPP2RY12PRKAG1PRKAA1
SCHEMBL29581997 0.94 TYMP (0.43) PRMT6TYMPP2RY12PRKAG1PRKAA1
SCHEMBL25873876 0.94 TYMP (0.43) PRMT6TYMPP2RY12PRKAG1PRKAA1
SCHEMBL26535891 0.94 TYMP (0.43) PRMT6TYMPP2RY12PRKAG1PRKAA1
SCHEMBL668595 0.94 TYMP (0.43) PRMT6TYMPP2RY12PRKAG1PRKAA1
SCHEMBL31588239 0.93 TYMP (0.42) PRMT6TYMPP2RY12PRKAG1PRKAA1
SCHEMBL2258922 0.92 TYMP (0.43) PRMT6TYMPP2RY12PRKAG1PRKAA1
SCHEMBL17861065 0.92 TYMP (0.42) PRMT6TYMPPRKAG1PRKAA1PRKAB1
SCHEMBL24829612 0.92 TYMP (0.41) PRMT6TYMPP2RY12PRKAG1PRKAA1
SCHEMBL23668111 0.91 TYMP (0.41) PRMT6TYMPP2RY12PRKAG1PRKAA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8252919-B2 2′-hydroxy-protected ribonucleoside derivative and production method thereof KANEKA CORPORATION (JP) 2012-08-28 — — US disclosed
US-20110009609-A1 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF KANEKA CORPORATION (JP) 2011-01-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009609-A1 2'-HYDROXY-PROTECTED RIBONUCLEOSIDE DERIVATIVE AND PRODUCTION METHOD THEREOF RNASEL, RNASEH1, NUDT1 PRMT6 2485/4885TYMP 183/4885P2RY12 3020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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