SCHEMBL9182158

SCHEMBL9182158

O=[N+]([O-])c1cc(SC(F)(F)F)ccc1Cl

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 10/20 0.47
TDP1 Q9NUW8 2/20 0.46
ALDH1A1 P00352 3/20 0.42
TSHR P16473 2/20 0.42
CYP3A4 P08684 2/20 0.42
HPGD P15428 2/20 0.42
ALOX15 P16050 1/20 0.42
HIF1A Q16665 1/20 0.42
TXNRD1 Q16881 1/20 0.42
TXNRD3 Q86VQ6 1/20 0.42
TXNRD2 Q9NNW7 1/20 0.42
PDE7A Q13946 1/20 0.42
MAPK1 P28482 2/20 0.41
MEN1 O00255 1/20 0.40
LMNA P02545 1/20 0.40
POLB P06746 1/20 0.40
MAPT P10636 1/20 0.40
XBP1 P17861 1/20 0.40
KMT2A Q03164 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5861079 0.80 VCAM1 (0.55) VCAM1TDP1TSHRPDE7AMAPK1
SCHEMBL18657403 0.80 PDE7A (0.60) VCAM1TDP1TSHRPDE7AMAPK1
SCHEMBL30387572 0.80 VCAM1 (0.55) VCAM1TDP1TSHRPDE7AMAPK1
SCHEMBL12708550 0.80 ALDH1A1 (0.50) TDP1ALDH1A1TSHRCYP3A4MAPK1
SCHEMBL7750760 0.80 TDP1 (0.53) TDP1ALDH1A1TSHRCYP3A4ALOX15
SCHEMBL1025631 0.80 MAPK1 (0.51) ALDH1A1TSHRCYP3A4HPGDALOX15
SCHEMBL15947438 0.78 GPR35 (0.54) TDP1ALDH1A1TSHRCYP3A4HPGD
SCHEMBL2080483 0.77 VCAM1 (0.51) VCAM1TDP1ALDH1A1HPGDPDE7A
SCHEMBL21573611 0.77 VCAM1 (0.54) VCAM1TDP1ALDH1A1TSHRCYP3A4
SCHEMBL5861086 0.77 VCAM1 (0.51) VCAM1TDP1TSHRPDE7AMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1039415-C Heterocyclic compounds ZENECA LTD (GB) 1998-08-05 CN disclosed
US-5451594-A NEMATOCIDES, INSECTICIDES, MITICIDES AND FUNGICIDES ZENECA LIMITED (GB) 1995-09-19 US disclosed
EP-0660830-A1 BENZOXAZOLE AND BEZOTHIAZOLE DERIVATIVES ZENECA LIMITED (GB) 1995-07-05 EP disclosed
CN-1094400-A Heterogeneous ring compound ZENECA LTD (GB) 1994-11-02 CN disclosed
WO-1994006782-A1 BENZOXAZOLE AND BEZOTHIAZOLE DERIVATIVES ZENECA LIMITED (GB) 1994-03-31 WO disclosed
WO-1994006783-A1 BENZOXAZOLE AND BENZOTHIAZOLE DERIVATIVES ZENECA LIMITED (GB) 1994-03-31 WO disclosed