Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 9/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 6/20 | 0.95 |
| ▸ | FLT3 | P36888 | 1/20 | 0.81 |
| ▸ | RAB9A | P51151 | 6/20 | 0.78 |
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.72 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | TNF | P01375 | 1/20 | 0.65 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5455846 | 0.90 | FLT3 (1.00) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL8289414 | 0.87 | FLT3 (0.96) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL3916274 | 0.86 | KMT2A (0.97) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL919352 | 0.85 | MEN1 (1.00) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL918754 | 0.84 | MEN1 (0.98) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL918590 | 0.84 | MEN1 (0.79) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL21247366 | 0.84 | RAB9A (1.00) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL3038723 | 0.83 | MEN1 (0.72) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL12218142 | 0.82 | MAPT (0.70) | MEN1KMT2AMAPTTP53NPC1 | |
| SCHEMBL20340283 | 0.82 | MAPT (0.96) | MEN1KMT2AMAPTTP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | claimed |
| US-20200369682-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO PHARMA (FR) | 2020-11-26 | — | — | US | disclosed |
| US-9789095-B2 | Inhibitors of calcium-activated chloride channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-9789095-B2 | Inhibitors of calcium-activated chloride channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-9789095-B2 | Inhibitors of calcium-activated chloride channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | UNIV CALIFORNIA (US) | 2015-10-15 | — | — | US | disclosed |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | UNIV CALIFORNIA (US) | 2015-10-15 | — | — | US | disclosed |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | UNIV CALIFORNIA (US) | 2015-10-15 | — | — | US | disclosed |
| US-8822462-B2 | Subunit selective NMDA receptor potentiators for the treatment of neurological conditions | EMORY UNIVERSITY (US) | 2014-09-02 | — | — | US | disclosed |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-06 | — | — | US | disclosed |
| US-20120028977-A1 | Subunit Selective NMDA Receptor Potentiators For The Treatment Of Neurological Conditions | EMORY UNIVERSITY (US) | 2012-02-02 | — | — | US | disclosed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | disclosed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | disclosed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2009079373-A2 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028977-A1 | Subunit Selective NMDA Receptor Potentiators For The Treatment Of Neurological Conditions | GRIN1, GRIN2A, GRIN2B | MEN1 4250/4885KMT2A 2345/4885MAPT 768/4885 |
| US-20200369682-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | FTH1, SLC40A1, FECH | MEN1 3538/4885KMT2A 3454/4885MAPT 2107/4885 |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | CLCN2, CLIC1, CLIC4 | MEN1 2082/4885KMT2A 4330/4885MAPT 655/4885 |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | CLCN2, CLIC1, CLIC4 | MEN1 2082/4885KMT2A 4330/4885MAPT 655/4885 |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | CLCN2, CLIC1, CLIC4 | MEN1 1808/4885KMT2A 4320/4885MAPT 727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.