Sugi Predict

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SCHEMBL918679

SCHEMBL918679

Cc1cccc(NC(=O)c2c(NC(=O)CCC(=O)O)sc3c2CCC(C(C)(C)C)C3)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 9/20 0.67
▸ POLB P06746 4/20 0.67
▸ TP53 P04637 3/20 0.67
▸ LMNA P02545 1/20 0.57
▸ MEN1 O00255 3/20 0.55
▸ ALDH1A1 P00352 3/20 0.55
▸ KMT2A Q03164 3/20 0.55
▸ KDM4E B2RXH2 2/20 0.55
▸ SMN1; SMN2 Q16637 2/20 0.55
▸ HTT P42858 1/20 0.55
▸ CASP6 P55212 1/20 0.55
▸ PKM P14618 1/20 0.54
▸ PDE4B Q07343 1/20 0.53
▸ BLM P54132 1/20 0.51
▸ ANO1 Q5XXA6 1/20 0.50
▸ NPC1 O15118 1/20 0.50
▸ HPGD P15428 1/20 0.50
▸ RAB9A P51151 1/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ THRB P10828 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL919331 0.83 MAPT (0.70) MAPTPOLBTP53LMNAMEN1
SCHEMBL4149735 0.83 MAPT (0.70) MAPTPOLBTP53LMNAMEN1
SCHEMBL29404234 0.83 POLB (0.49) MAPTPOLBTP53LMNAMEN1
SCHEMBL918266 0.79 POLB (0.64) MAPTPOLBTP53LMNAALDH1A1
SCHEMBL918255 0.78 KDM4E (0.66) MAPTPOLBTP53MEN1ALDH1A1
SCHEMBL8289737 0.77 MAPT (0.58) MAPTPOLBTP53LMNAMEN1
SCHEMBL21260640 0.75 MAPT (0.81) MAPTPOLBTP53LMNAMEN1
SCHEMBL918839 0.73 ALDH1A1 (0.67) MAPTPOLBTP53ALDH1A1KMT2A
SCHEMBL21260639 0.72 ANO1 (0.69) MAPTPOLBTP53MEN1ALDH1A1
SCHEMBL918990 0.70 MAPT (0.77) MAPTPOLBTP53LMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3562818-B1 THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS ENYO PHARMA (FR) 2022-05-18 — — EP claimed
CN-110114349-B Thiophene derivatives as antiviral agents 埃尼奥制药公司 2022-03-15 — — CN claimed
US-20190352275-A1 THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS ENYO PHARMA (FR) 2019-11-21 — — US claimed
US-9789095-B2 Inhibitors of calcium-activated chloride channels THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-10-17 — — US claimed
US-20110015239-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-01-20 — — US claimed
US-11807618-B2 Thiophene derivatives as antiviral agents ENYO PHARMA (FR) 2023-11-07 — — US disclosed
US-20220213053-A1 THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS ENYO PHARMA (FR) 2022-07-07 — — US disclosed
EP-3562818-B1 THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS ENYO PHARMA (FR) 2022-05-18 — — EP disclosed
US-11279683-B2 Thiophene derivatives as antiviral agents ENYO PHARMA (FR) 2022-03-22 — — US disclosed
CN-110114349-B Thiophene derivatives as antiviral agents 埃尼奥制药公司 2022-03-15 — — CN disclosed
US-20190352275-A1 THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS ENYO PHARMA (FR) 2019-11-21 — — US disclosed
US-9789095-B2 Inhibitors of calcium-activated chloride channels THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-10-17 — — US disclosed
US-20150290175-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS UNIV CALIFORNIA (US) 2015-10-15 — — US disclosed
US-20130143765-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-06-06 — — US disclosed
US-20130143765-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-06-06 — — US disclosed
US-20130143765-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2013-06-06 — — US disclosed
US-20110015239-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-01-20 — — US disclosed
US-20110015239-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-01-20 — — US disclosed
US-20110015239-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2011-01-20 — — US disclosed
WO-2009079373-A2 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-06-25 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220213053-A1 THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS MAVS, EIF2AK2, IRF3 MAPT 3934/4885POLB 369/4885TP53 1353/4885
US-11279683-B2 Thiophene derivatives as antiviral agents MAVS, EIF2AK2, IRF3 MAPT 4150/4885POLB 287/4885TP53 2656/4885
US-20130143765-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS CLCN2, CLIC1, CLIC4 MAPT 655/4885POLB 4777/4885TP53 2566/4885
US-20190352275-A1 THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS MAVS, EIF2AK2, IRF3 MAPT 4150/4885POLB 287/4885TP53 2656/4885
US-20150290175-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS CLCN2, CLIC1, CLIC4 MAPT 655/4885POLB 4777/4885TP53 2566/4885
US-11807618-B2 Thiophene derivatives as antiviral agents MAVS, EIF2AK2, IRF3 MAPT 3934/4885POLB 369/4885TP53 1353/4885
US-20110015239-A1 INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS CLCN2, CLIC1, CLIC4 MAPT 727/4885POLB 4773/4885TP53 2405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.