Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | THRB | P10828 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918266 | 0.91 | POLB (0.64) | KDM4EALDH1A1SMN1; SMN2HPGDTHRB | |
| SCHEMBL918839 | 0.85 | ALDH1A1 (0.67) | KDM4EALDH1A1THRBMAPTPOLB | |
| SCHEMBL919327 | 0.83 | THRB (0.59) | KDM4EALDH1A1SMN1; SMN2HPGDTHRB | |
| SCHEMBL919329 | 0.83 | THRB (0.59) | KDM4EALDH1A1SMN1; SMN2HPGDTHRB | |
| SCHEMBL6201333 | 0.83 | ALDH1A1 (0.65) | KDM4EALDH1A1SMN1; SMN2HPGDTHRB | |
| SCHEMBL917815 | 0.82 | MAPT (0.72) | KDM4EALDH1A1SMN1; SMN2HPGDTHRB | |
| SCHEMBL8289737 | 0.81 | MAPT (0.58) | KDM4EALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL12768295 | 0.81 | THRB (0.56) | KDM4EALDH1A1THRBMAPTPOLB | |
| SCHEMBL8288716 | 0.81 | ALDH1A1 (0.98) | KDM4EALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL919331 | 0.79 | MAPT (0.70) | KDM4EALDH1A1SMN1; SMN2THRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9789095-B2 | Inhibitors of calcium-activated chloride channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | claimed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | claimed |
| US-20200369682-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | ENYO PHARMA (FR) | 2020-11-26 | — | — | US | disclosed |
| US-9789095-B2 | Inhibitors of calcium-activated chloride channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-9789095-B2 | Inhibitors of calcium-activated chloride channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-9789095-B2 | Inhibitors of calcium-activated chloride channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | UNIV CALIFORNIA (US) | 2015-10-15 | — | — | US | disclosed |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | UNIV CALIFORNIA (US) | 2015-10-15 | — | — | US | disclosed |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | UNIV CALIFORNIA (US) | 2015-10-15 | — | — | US | disclosed |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-06 | — | — | US | disclosed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | disclosed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | disclosed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2009079373-A2 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-25 | — | — | WO | disclosed |
| WO-2005033102-A2 | THIOPHENE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200369682-A1 | FUSED THIOPHENE DERIVATIVES AND THEIR USES | FTH1, SLC40A1, FECH | KDM4E 3018/4885ALDH1A1 2143/4885SMN1; SMN2 4008/4885 |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | CLCN2, CLIC1, CLIC4 | KDM4E 4228/4885ALDH1A1 3981/4885SMN1; SMN2 3546/4885 |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | CLCN2, CLIC1, CLIC4 | KDM4E 4228/4885ALDH1A1 3981/4885SMN1; SMN2 3546/4885 |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | CLCN2, CLIC1, CLIC4 | KDM4E 4211/4885ALDH1A1 3888/4885SMN1; SMN2 3632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.