Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.70 |
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | TP53 | P04637 | 6/20 | 0.66 |
| ▸ | POLB | P06746 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918679 | 0.83 | MAPT (0.67) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL918266 | 0.83 | POLB (0.64) | MAPTTP53POLBALDH1A1KDM4E | |
| SCHEMBL29403797 | 0.82 | MAPT (0.56) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL918255 | 0.79 | KDM4E (0.66) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL21247250 | 0.79 | THRB (0.68) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL8289737 | 0.78 | MAPT (0.58) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL918839 | 0.78 | ALDH1A1 (0.67) | MAPTKMT2ATP53POLBALDH1A1 | |
| SCHEMBL21247230 | 0.77 | THRB (0.79) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL21260652 | 0.74 | MAPT (0.61) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL12768295 | 0.74 | THRB (0.56) | MAPTKMT2ATP53POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3562818-B1 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS | ENYO PHARMA (FR) | 2022-05-18 | — | — | EP | claimed |
| CN-110114349-B | Thiophene derivatives as antiviral agents | 埃尼奥制药公司 | 2022-03-15 | — | — | CN | claimed |
| US-20190352275-A1 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS | ENYO PHARMA (FR) | 2019-11-21 | — | — | US | claimed |
| US-9789095-B2 | Inhibitors of calcium-activated chloride channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | claimed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | claimed |
| US-11807618-B2 | Thiophene derivatives as antiviral agents | ENYO PHARMA (FR) | 2023-11-07 | — | — | US | disclosed |
| US-20220213053-A1 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS | ENYO PHARMA (FR) | 2022-07-07 | — | — | US | disclosed |
| EP-3562818-B1 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS | ENYO PHARMA (FR) | 2022-05-18 | — | — | EP | disclosed |
| US-11279683-B2 | Thiophene derivatives as antiviral agents | ENYO PHARMA (FR) | 2022-03-22 | — | — | US | disclosed |
| CN-110114349-B | Thiophene derivatives as antiviral agents | 埃尼奥制药公司 | 2022-03-15 | — | — | CN | disclosed |
| US-20190352275-A1 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS | ENYO PHARMA (FR) | 2019-11-21 | — | — | US | disclosed |
| US-9789095-B2 | Inhibitors of calcium-activated chloride channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-10-17 | — | — | US | disclosed |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | UNIV CALIFORNIA (US) | 2015-10-15 | — | — | US | disclosed |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-06 | — | — | US | disclosed |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-06-06 | — | — | US | disclosed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | disclosed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | disclosed |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-01-20 | — | — | US | disclosed |
| WO-2009079373-A2 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213053-A1 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS | MAVS, EIF2AK2, IRF3 | MAPT 3934/4885MEN1 4801/4885KMT2A 4026/4885 |
| US-11279683-B2 | Thiophene derivatives as antiviral agents | MAVS, EIF2AK2, IRF3 | MAPT 4150/4885MEN1 4697/4885KMT2A 4304/4885 |
| US-20130143765-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | CLCN2, CLIC1, CLIC4 | MAPT 655/4885MEN1 2082/4885KMT2A 4330/4885 |
| US-20190352275-A1 | THIOPHENE DERIVATIVES AS ANTIVIRAL AGENTS | MAVS, EIF2AK2, IRF3 | MAPT 4150/4885MEN1 4697/4885KMT2A 4304/4885 |
| US-20150290175-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | CLCN2, CLIC1, CLIC4 | MAPT 655/4885MEN1 2082/4885KMT2A 4330/4885 |
| US-11807618-B2 | Thiophene derivatives as antiviral agents | MAVS, EIF2AK2, IRF3 | MAPT 3934/4885MEN1 4801/4885KMT2A 4026/4885 |
| US-20110015239-A1 | INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS | CLCN2, CLIC1, CLIC4 | MAPT 727/4885MEN1 1808/4885KMT2A 4320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.