Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL920771 | 0.94 | TAAR1 (0.53) | TAAR1MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL919297 | 0.92 | TAAR1 (0.52) | TAAR1MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL680547 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL1027465 | 0.86 | TAAR1 (0.52) | TAAR1MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7533129 | 0.81 | TAAR1 (0.52) | TAAR1MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL20135772 | 0.80 | TAAR1 (0.73) | TAAR1SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL20146704 | 0.80 | TAAR1 (0.73) | TAAR1SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL6685935 | 0.80 | TAAR1 (0.55) | TAAR1SMN1; SMN2NPC1RAB9ATSHR | |
| SCHEMBL22067943 | 0.79 | TAAR1 (0.50) | TAAR1MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8571535 | 0.78 | TAAR1 (0.70) | TAAR1SMN1; SMN2NPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111225901-B | Propylamine derivatives for the treatment of pain and pain-related disorders | 埃斯特韦制药股份公司 | 2023-07-04 | — | — | CN | claimed |
| EP-3558983-A1 | NITROGEN CONTAINING BICYCLIC DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-10-30 | — | — | EP | claimed |
| EP-3558965-A1 | NEW QUINOLINE AND ISOQUINOLINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-10-30 | — | — | EP | claimed |
| WO-2018115069-A1 | NITROGEN CONTAINING BICYCLIC DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2018-06-28 | — | — | WO | claimed |
| WO-2018115064-A1 | NEW QUINOLINE AND ISOQUINOLINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2018-06-28 | — | — | WO | claimed |
| US-12492195-B2 | Preparation method for and crystal form of 3-aryloxy-3-five-membered heteroaryl-propylamine compound | ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL CO., LTD. (CN) | 2025-12-09 | — | — | US | disclosed |
| CN-115135644-B | Preparation method and crystal form of 3-aryloxy-3-five-membered heteroaryl-propylamine compound | 漳州片仔癀药业股份有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-112654616-B | 3-aryloxy-3-aryl-propylamines and application thereof | 漳州片仔癀药业股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-111225901-B | Propylamine derivatives for the treatment of pain and pain-related disorders | 埃斯特韦制药股份公司 | 2023-07-04 | — | — | CN | disclosed |
| EP-4105212-A1 | PREPARATION METHOD FOR AND CRYSTAL FORM OF 3-ARYLOXY-3-FIVE-MEMBERED HETEROARYL-PROPYLAMINE COMPOUND | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. (CN) | 2022-12-21 | — | — | EP | disclosed |
| EP-4076668-A1 | COMPOSITION AND METHOD FOR TREATING DERMATOLOGICAL DISORDERS USING RETINAMIDES | University of Maryland, Baltimore (US) | 2022-10-26 | — | — | EP | disclosed |
| CN-115135644-A | Preparation method and crystal form of 3-aryloxy-3-pentabasic heteroaryl-propylamine compound | 漳州片仔癀药业股份有限公司 | 2022-09-30 | — | — | CN | disclosed |
| WO-2009109992-A1 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE AND INTERMEDIATES FOR USE THEREIN | ARCH PHARMALABS LIMITED (IN) | 2009-09-11 | — | — | WO | disclosed |
| WO-2008126684-A2 | AGRICULTURAL COMPOSITION FOR CONTROLLING OR PREVENTING PLANT DISEASES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2008-10-23 | — | — | WO | disclosed |
| EP-1263711-B1 | NOVEL USE OF PHENYLHETEROALKYLAMINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-12-15 | — | — | EP | disclosed |
| US-20040249170-A1 | Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine | BORGHESE ALFIO (BE) | 2004-12-09 | — | — | US | disclosed |
| EP-1478641-A1 | PROCESS FOR PREPARING AN INTERMEDIATE USEFUL FOR THE ASYMMETRIC SYNTHESIS OF DULOXETINE | ELI LILLY AND COMPANY (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003062219-A1 | PROCESS FOR PREPARING AN INTERMEDIATE USEFUL FOR THE ASYMMETRIC SYNTHESIS OF DULOXETINE | ELI LILLY AND COMPANY (US) | 2003-07-31 | — | — | WO | disclosed |
| US-4737495-A | ANTIALLERGENS, ANTISCHEMIC, HYPOTENSIVE AGENTS | DR. KARL TOMAE, GMBH (DE) | 1988-04-12 | — | — | US | disclosed |
| EP-0204349-A2 | Heteroaromatic amine derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1986-12-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12492195-B2 | Preparation method for and crystal form of 3-aryloxy-3-five-membered heteroaryl-propylamine compound | TRPC7, TRPV1, TRPC5 | TAAR1 337/4885MEN1 1938/4885KMT2A 3774/4885 |
| US-20040249170-A1 | Process for preparing an intermediate useful for the asymmetric synthesis of duloxetine | PNMT, HTR1A, TPH1 | TAAR1 251/4885MEN1 3661/4885KMT2A 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.