Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | GCGR | P47871 | 2/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9193870 | 0.89 | RXRA (0.51) | TGFBR1TBXAS1MAPTMAPK13MAPK12 | |
| SCHEMBL9200921 | 0.88 | TGFBR1 (0.46) | TGFBR1TBXAS1MAPTMAPK13MAPK12 | |
| SCHEMBL9201256 | 0.85 | MAPT (0.49) | TGFBR1LTB4RMAPTMAPK13MAPK12 | |
| SCHEMBL7267240 | 0.77 | CHRM1 (0.55) | TGFBR1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL8119778 | 0.74 | FAAH (0.52) | MAPTMEN1KMT2ASMN1; SMN2 | |
| Sebacic Acid SCHEMBL6745956 | 0.73 | LMNA (0.55) | ESR1ESR2LTB4RMAPTMEN1 | |
| Azelaic Acid SCHEMBL9777688 | 0.73 | LMNA (0.55) | ESR1ESR2LTB4RMAPTMEN1 | |
| SCHEMBL6745959 | 0.73 | LMNA (0.55) | ESR1ESR2LTB4RMAPTMEN1 | |
| SCHEMBL9194754 | 0.72 | FAAH (0.43) | TGFBR1TBXAS1MAPTMAPK13MAPK12 | |
| SCHEMBL9201163 | 0.72 | NOX1 (0.44) | MAPTTP53MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626969-A4 | CoA-IT AND PAF INHIBITORS. | SMITHKLINE BEECHAM CORP (US) | 1995-04-19 | — | — | EP | disclosed |
| EP-0626969-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-07 | — | — | EP | disclosed |
| WO-1993016674-A1 | CoA-IT AND PAF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |