Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | MFN2 | O95140 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198495 | 0.86 | ALDH1A1 (0.39) | XIAPLMNACHRM2ADRA2ACYP2D6 | |
| SCHEMBL9199668 | 0.85 | XIAP (0.37) | HSD11B1XIAPLMNACHRM2ADRA2A | |
| SCHEMBL9199610 | 0.77 | XIAP (0.40) | XIAPLMNAMAPTHTR2B | |
| SCHEMBL6606184 | 0.76 | LDHA (0.45) | XIAPLMNASIGMAR1HTR2B | |
| SCHEMBL9195240 | 0.70 | LDHA (0.38) | XIAPOPRM1 | |
| SCHEMBL9199838 | 0.69 | GAA (0.35) | XIAPLMNACHRM2ADRA2ACYP2D6 | |
| SCHEMBL6603207 | 0.67 | LDHA (0.47) | XIAPLMNACHRM2ADRA2ACYP2D6 | |
| SCHEMBL9198735 | 0.66 | LDHA (0.41) | OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL6609678 | 0.61 | LDHA (0.40) | OPRM1KMT2A | |
| SCHEMBL6604456 | 0.60 | LDHA (0.48) | CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | claimed |