Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12661473 | 0.84 | POLB (0.73) | DRD2DRD3POLBGAATDP1 | |
| SCHEMBL3436048 | 0.80 | POLB (0.55) | DRD2DRD3POLBTDP1MITF | |
| SCHEMBL5319656 | 0.80 | KDM4E (0.70) | POLBTDP1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9200779 | 0.79 | ADRA1A (0.57) | DRD2DRD3POLBTDP1MITF | |
| Ammonia Solution, Strong SCHEMBL4267670 | 0.79 | KDM4E (0.68) | POLBTDP1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL12818306 | 0.79 | SIGMAR1 (0.77) | DRD2HTR2B | |
| SCHEMBL17848474 | 0.78 | DRD2 (0.58) | DRD2TDP1HTR1AHTR7ALDH1A1 | |
| SCHEMBL8114904 | 0.78 | LTA4H (0.61) | TDP1SMN1; SMN2KDM4EALDH1A1LTA4H | |
| SCHEMBL6945688 | 0.78 | LTA4H (0.61) | TDP1SMN1; SMN2KDM4EALDH1A1LTA4H | |
| SCHEMBL8690263 | 0.77 | DRD2 (0.46) | DRD2DRD3POLBTDP1MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0520882-B1 | 2-Aminopyrimidin-4-carboxamide derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1995-07-12 | — | — | EP | disclosed |
| US-5246939-A | Antiadrenergic systems for lower urinary apparatus | SYNTHELABO (FR) | 1993-09-21 | — | — | US | disclosed |
| EP-0520882-A1 | 2-Aminopyrimidin-4-carboxamide derivatives, their preparation and their application in therapy | SYNTHELABO (FR) | 1992-12-30 | — | — | EP | disclosed |