Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | CA5A | P35218 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 4/20 | 0.43 |
| ▸ | GABBR1 | Q9UBS5 | 4/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9315754 | 0.84 | PIM1 (0.55) | CA12CA1CA2CA9ADAM17 | |
| SCHEMBL9203506 | 0.84 | LMNA (0.43) | CA12CA2CA4CA6CA7 | |
| SCHEMBL9198993 | 0.84 | GABBR2 (0.44) | GABBR2GABBR1LMNACYP2C9ADORA3 | |
| SCHEMBL9202393 | 0.83 | GABBR2 (0.54) | MAOBADAM17MMP2GABBR2GABBR1 | |
| SCHEMBL9196666 | 0.83 | GABBR2 (0.43) | CA12CA1CA2CA9GABBR2 | |
| SCHEMBL9195312 | 0.81 | GAA (0.43) | GABBR2GABBR1LMNACYP2C9ADORA3 | |
| SCHEMBL9200327 | 0.81 | ALDH1A1 (0.45) | MAOBCA12CA1CA4CA6 | |
| SCHEMBL9594099 | 0.80 | PIM1 (0.57) | MAOBMMP2GABBR2GABBR1MMP9 | |
| SCHEMBL658890 | 0.78 | MAOB (0.47) | MAOBCA12CA1CA2CA4 | |
| SCHEMBL9316733 | 0.75 | TAS1R3 (0.48) | MAOBCA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0463969-B1 | New compounds of 4-aminobutyric acid, process for their preparation and pharmaceutical preparations containing them | ADIR (FR) | 1995-02-08 | — | — | EP | claimed |
| US-5278166-A | 4-amino-3-heteroaryl butyric acid compounds, compositions, and their use for treating disorders involving a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1994-01-11 | — | — | US | disclosed |
| US-5214063-A | 4-aminobutyric acid compounds, compositions and methods of use for treating disorders related to a dysfunction of GABAB receptors | ADIR ET COMPAGNIE (FR) | 1993-05-25 | — | — | US | disclosed |
| US-5162364-A | Treatment of spastic and senescence disorders | ADIR ET COMPAGNIE (FR) | 1992-11-10 | — | — | US | disclosed |