Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 2/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 2/20 | 0.37 |
| ▸ | MAX | P61244 | 2/20 | 0.37 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8813862 | 0.99 | THRA (0.40) | THRATHRBEP300SLC9A1ALDH1A1 | |
| SCHEMBL9189526 | 0.91 | PKM (0.43) | EP300ALDH1A1HIF1AGPR55 | |
| SCHEMBL9189972 | 0.83 | PKM (0.49) | ALDH1A1 | |
| SCHEMBL8816709 | 0.82 | SMPD1 (0.52) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8816482 | 0.82 | PKM (0.48) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8814867 | 0.81 | SMPD1 (0.51) | ALDH1A1 | |
| SCHEMBL8917612 | 0.81 | THRA (0.41) | THRATHRBALDH1A1 | |
| SCHEMBL8068683 | 0.80 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL8743820 | 0.80 | SLC9A1 (0.40) | SLC9A1ALDH1A1SLC9A2 | |
| SCHEMBL9196826 | 0.79 | SLC9A1 (0.62) | SLC9A1SLC9A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416499-B1 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AG (DE) | 1995-04-26 | — | — | EP | disclosed |
| US-5292755-A | USPA benzolyguanidines | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-08 | — | — | US | disclosed |
| US-5091394-A | BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |
| EP-0416499-A2 | Benzoylguanidines, process for their preparation, their use as medicaments as well as medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-13 | — | — | EP | disclosed |