Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 6/20 | 0.37 |
| ▸ | RARA | P10276 | 2/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916182 | 0.84 | VCAM1 (0.45) | THRATHRBMAPTCTNNB1RARG | |
| SCHEMBL9189972 | 0.82 | PKM (0.49) | MAPTF10LMNAALDH1A1MEN1 | |
| SCHEMBL8917633 | 0.81 | SLC9A1 (0.51) | — | |
| Hydrochloric Acid SCHEMBL8816482 | 0.81 | PKM (0.48) | MAPTF10LMNAALDH1A1MEN1 | |
| SCHEMBL9196819 | 0.81 | THRA (0.40) | THRATHRBALDH1A1 | |
| Hydrochloric Acid SCHEMBL8813862 | 0.80 | THRA (0.40) | THRATHRBMAPTALDH1A1GAA | |
| SCHEMBL8816709 | 0.79 | SMPD1 (0.52) | MAPTF10ALDH1A1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL8814867 | 0.78 | SMPD1 (0.51) | MAPTF10ALDH1A1KDM4EMEN1 | |
| SCHEMBL8068683 | 0.77 | SMN1; SMN2 (0.41) | MAPTF10LMNAKDM4E | |
| Hydrochloric Acid SCHEMBL8059609 | 0.76 | SMN1; SMN2 (0.40) | MAPTF10LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670544-A | ANTIISCHEMIC AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0602522-B1 | Substituted Benzoylguanidines, method for their preparation, their use as antiarrhythmic agents | HOECHST AG (DE) | 1996-05-29 | — | — | EP | disclosed |
| EP-0602522-A1 | Substituted Benzoylguanidines, method for their preparation, their use as antiarrhythmic agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-06-22 | — | — | EP | disclosed |