Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ABCC9 | O60706 | 5/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 5/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 5/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9680848 | 0.87 | KCNE1 (0.46) | ABCC9KCNE1KCNQ1ABCB1L3MBTL1 | |
| SCHEMBL9680855 | 0.86 | KCNE1 (0.47) | LMNAABCC9KCNE1KCNQ1 | |
| SCHEMBL9192059 | 0.85 | KCNE1 (0.43) | LMNAABCC9KCNE1KCNQ1ABCB1 | |
| SCHEMBL9680937 | 0.83 | ABCC9 (0.40) | LMNAABCC9KCNE1KCNQ1L3MBTL1 | |
| SCHEMBL9193528 | 0.83 | ABCB1 (0.52) | LMNAABCC9KCNE1KCNQ1ABCB1 | |
| SCHEMBL9193747 | 0.83 | TYK2 (0.36) | ABCC9 | |
| SCHEMBL9681478 | 0.81 | ALOX5 (0.40) | ABCC9L3MBTL1KCNA5 | |
| SCHEMBL9680959 | 0.79 | ALDH1A1 (0.41) | MAPK1ABCC9L3MBTL1KDM4EKCNA5 | |
| SCHEMBL9199563 | 0.78 | ABCC9 (0.38) | LMNAABCC9KCNE1KCNQ1L3MBTL1 | |
| SCHEMBL9127063 | 0.77 | IGF1R (0.39) | ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112839-A | CHROMAN DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-05-12 | — | — | US | disclosed |
| EP-0406656-A1 | Chroman derivatives | MERCK PATENT GmbH (DE) | 1991-01-09 | — | — | EP | disclosed |