Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9698919 | 0.86 | TGFBR1 (0.44) | ATMNPC1RAB9ASMN1; SMN2TGFBR1 | |
| SCHEMBL10379982 | 0.85 | PDE10A (0.41) | ATMNPC1RAB9ASMN1; SMN2TGFBR1 | |
| SCHEMBL11477397 | 0.75 | ATM (0.72) | ATMNPC1RAB9ASMN1; SMN2TGFBR1 | |
| SCHEMBL15452608 | 0.71 | TGFBR1 (0.72) | ATMNPC1RAB9ASMN1; SMN2TGFBR1 | |
| SCHEMBL7381132 | 0.70 | TGFBR1 (0.67) | ATMNPC1RAB9ASMN1; SMN2TGFBR1 | |
| SCHEMBL9840193 | 0.70 | CASP3 (0.41) | ATMNPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL9196852 | 0.69 | ATM (0.67) | ATMNPC1RAB9ASMN1; SMN2TGFBR1 | |
| SCHEMBL11482604 | 0.67 | MAPT (0.59) | ATMNPC1RAB9ASMN1; SMN2TGFBR1 | |
| SCHEMBL9436323 | 0.67 | TGFBR1 (0.63) | ATMNPC1RAB9ASMN1; SMN2TGFBR1 | |
| SCHEMBL9700033 | 0.67 | TGFBR1 (0.83) | ATMNPC1RAB9ASMN1; SMN2TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0306300-B1 | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORP (US) | 1995-05-03 | — | — | EP | claimed |
| US-5002941-A | Antiarthritic agents, arachidonic acid metabolism | SMITHKLINE BEECHAM CORPORATION (US) | 1991-03-26 | — | — | US | claimed |
| EP-0306300-B1 | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORP (US) | 1995-05-03 | — | — | EP | disclosed |
| US-5145858-A | Antiinflammatory | SMITHKLINE BEECHAM CORP. (US) | 1992-09-08 | — | — | US | disclosed |
| US-5002941-A | Antiarthritic agents, arachidonic acid metabolism | SMITHKLINE BEECHAM CORPORATION (US) | 1991-03-26 | — | — | US | disclosed |
| WO-1990003789-A1 | PYRROLO[1,2-a]IMIDAZOLE AND IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR USE AS 5-LYPOXYGENASE PATHWAY INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-19 | — | — | WO | disclosed |
| EP-0364204-A1 | Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-18 | — | — | EP | disclosed |
| EP-0306300-A2 | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-03-08 | — | — | EP | disclosed |