Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379982 | 0.87 | PDE10A (0.41) | TGFBR1ATMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9197916 | 0.86 | ATM (0.58) | TGFBR1ATMNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9436258 | 0.72 | TGFBR1 (0.69) | TGFBR1TGFBR2ATMNPC1RAB9A | |
| SCHEMBL990288 | 0.71 | SMN1; SMN2 (0.66) | TGFBR1TGFBR2ATMNPC1RAB9A | |
| SCHEMBL16739869 | 0.70 | MEN1 (0.36) | LMNA | |
| SCHEMBL9839144 | 0.68 | SIGMAR1 (0.37) | RAB9A | |
| SCHEMBL25269983 | 0.68 | GAA (0.48) | ATMCSNK1DLMNA | |
| SCHEMBL7248094 | 0.68 | MAPK14 (0.54) | CSNK1D | |
| SCHEMBL15823964 | 0.67 | SMN1; SMN2 (0.60) | TGFBR1TGFBR2ATMNPC1RAB9A | |
| SCHEMBL7343693 | 0.67 | TGFBR1 (0.65) | TGFBR1TGFBR2SMN1; SMN2CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145858-A | Antiinflammatory | SMITHKLINE BEECHAM CORP. (US) | 1992-09-08 | — | — | US | disclosed |
| US-5002941-A | Antiarthritic agents, arachidonic acid metabolism | SMITHKLINE BEECHAM CORPORATION (US) | 1991-03-26 | — | — | US | disclosed |
| WO-1990003789-A1 | PYRROLO[1,2-a]IMIDAZOLE AND IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR USE AS 5-LYPOXYGENASE PATHWAY INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-19 | — | — | WO | disclosed |
| EP-0364204-A1 | Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-18 | — | — | EP | disclosed |