Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197935 | 0.85 | CPB1 (0.31) | AGTR1AGTR2MAPTCPB1 | |
| SCHEMBL9207021 | 0.83 | MAPT (0.32) | AGTR1AGTR2MAPT | |
| SCHEMBL9287163 | 0.82 | TLR7 (0.37) | AGTR1AGTR2LMNA | |
| SCHEMBL9206193 | 0.79 | AGTR1 (0.33) | AGTR1AGTR2CYP1A2MAPTTSHR | |
| SCHEMBL9287158 | 0.78 | TLR7 (0.39) | AGTR1AGTR2 | |
| SCHEMBL9199466 | 0.76 | NR4A2 (0.41) | RAB9AKMT2A | |
| SCHEMBL9203204 | 0.76 | PLA2G2A (0.35) | AGTR1AGTR2MAPT | |
| SCHEMBL9196521 | 0.76 | HDAC8 (0.39) | AGTR1AGTR2MAPTTSHRRAB9A | |
| SCHEMBL9203639 | 0.75 | AGTR2 (0.32) | AGTR1AGTR2MAPT | |
| SCHEMBL9199463 | 0.73 | PLA2G2A (0.36) | AGTR1AGTR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0517812-A4 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO INC (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0517812-A1 | ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT | MERCK & CO. INC. (US) | 1992-12-16 | — | — | EP | disclosed |