SCHEMBL919953

SCHEMBL919953

Nc1nc(F)ccc1C(=O)NCc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 4/20 0.58
SORT1 Q99523 1/20 0.47
CYP3A4 P08684 2/20 0.47
PPARA Q07869 3/20 0.44
PPARG P37231 2/20 0.44
PPARD Q03181 2/20 0.44
HDAC1 Q13547 1/20 0.44
CHRM4 P08173 1/20 0.43
LMNA P02545 1/20 0.43
HTT P42858 1/20 0.43
MMP13 P45452 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
LSS P48449 1/20 0.43
LIPG Q9Y5X9 1/20 0.43
HPGD P15428 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921097 0.90 MAPK14 (0.47) MAPK14SORT1CYP3A4PPARAPPARG
SCHEMBL920920 0.90 MAPK14 (0.53) MAPK14PPARAPPARGPPARD
SCHEMBL920201 0.90 MAPK14 (0.56) MAPK14PPARAPPARGPPARDMMP13
SCHEMBL921739 0.89 PPARA (0.50) MAPK14SORT1PPARAPPARGPPARD
SCHEMBL922041 0.89 PPARA (0.46) MAPK14SORT1PPARAPPARGPPARD
SCHEMBL920391 0.89 EPHX2 (0.49) MAPK14CYP3A4PPARAPPARGPPARD
SCHEMBL920506 0.89 CYP3A4 (0.54) MAPK14CYP3A4PPARAPPARGPPARD
SCHEMBL921034 0.88 MAPK14 (0.57) MAPK14SORT1CYP3A4PPARAPPARG
SCHEMBL921469 0.87 MAPK14 (0.52) MAPK14CYP3A4PPARAPPARGLMNA
SCHEMBL921417 0.86 MAPK14 (0.43) MAPK14CYP3A4PPARAPPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK14 905/4885SORT1 4116/4885CYP3A4 3076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.