SCHEMBL921097

SCHEMBL921097

Nc1nc(F)ccc1C(=O)NCc1ccc(Oc2cc(F)cc(C(F)(F)F)c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 3/20 0.47
PPARG P37231 1/20 0.44
PPARD Q03181 1/20 0.44
PPARA Q07869 1/20 0.44
TLR8 Q9NR97 2/20 0.42
PTGER4 P35408 4/20 0.41
PTGER2 P43116 2/20 0.41
LIPG Q9Y5X9 1/20 0.41
SORT1 Q99523 1/20 0.41
CYP3A4 P08684 1/20 0.40
GPR52 Q9Y2T5 1/20 0.40
RECQL P46063 1/20 0.40
PIN1 Q13526 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920858 0.90 PPARG (0.47) MAPK14PPARGPPARDPPARATLR8
SCHEMBL919953 0.90 MAPK14 (0.58) MAPK14PPARGPPARDPPARALIPG
SCHEMBL920920 0.88 MAPK14 (0.53) MAPK14PPARGPPARDPPARATLR8
SCHEMBL922356 0.88 MAPK14 (0.44) MAPK14PPARGPPARDPPARAPTGER4
SCHEMBL920422 0.87 PPARA (0.43) MAPK14PPARGPPARDPPARATLR8
SCHEMBL920489 0.85 MAPK14 (0.48) MAPK14TLR8GPR52
SCHEMBL920506 0.85 CYP3A4 (0.54) MAPK14PPARGPPARDPPARAPTGER4
SCHEMBL919925 0.84 HTR2C (0.49) MAPK14PTGER4PTGER2LIPGCYP3A4
SCHEMBL921739 0.83 PPARA (0.50) MAPK14PPARGPPARDPPARAPTGER4
SCHEMBL922041 0.83 PPARA (0.46) MAPK14PPARGPPARDPPARAPTGER4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK14 905/4885PPARG 391/4885PPARD 360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.