Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096967 | 0.86 | ACACB (0.42) | LMNAKMT2ANNMTMEN1 | |
| SCHEMBL1398350 | 0.81 | CES2 (0.58) | LMNASMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27714789 | 0.79 | ALDH1A1 (0.55) | LMNASMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19664385 | 0.78 | KMT2A (0.43) | KMT2AALDH1A1MAPTMEN1CA2 | |
| SCHEMBL7869465 | 0.78 | ACACB (0.40) | LMNAKMT2AALDH1A1F2GLA | |
| SCHEMBL9191894 | 0.78 | TSHR (0.39) | KMT2AMAPT | |
| SCHEMBL9519014 | 0.78 | RAB9A (0.49) | LMNASMN1; SMN2KMT2AALDH1A1HPGD | |
| SCHEMBL7862661 | 0.77 | KDM4E (0.39) | LMNASMN1; SMN2KMT2AALDH1A1MAPT | |
| SCHEMBL9199674 | 0.75 | ACACB (0.39) | KMT2AMAPTMEN1 | |
| SCHEMBL8065698 | 0.75 | ESR2 (0.58) | LMNASMN1; SMN2CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278452-B1 | 2,4- and 2,5-Pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds | HOECHST AG (DE) | 1995-05-24 | — | — | EP | claimed |
| EP-0278452-B1 | 2,4- and 2,5-Pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds | HOECHST AG (DE) | 1995-05-24 | — | — | EP | disclosed |