Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.48 |
| ▸ | BCL9 | O00512 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.43 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26374 | 0.83 | GAA (0.65) | RAB9AGAAMAPTHSPB1BCL9 | |
| SCHEMBL7401922 | 0.82 | MAPT (0.49) | RAB9AGAAMAPTBCL9CTNNB1 | |
| Hydrochloric Acid SCHEMBL7895043 | 0.82 | GAA (0.62) | RAB9AGAAMAPTHSPB1BCL9 | |
| SCHEMBL9366960 | 0.79 | GAA (0.47) | GAAMAPTBCL9CTNNB1KMT2A | |
| SCHEMBL1639306 | 0.79 | GAA (0.59) | RAB9AGAAMAPTBCL9CTNNB1 | |
| SCHEMBL12736161 | 0.78 | MAPT (0.72) | RAB9AMAPTKMT2AMEN1POLB | |
| SCHEMBL21806518 | 0.78 | GAA (0.48) | RAB9AGAAMAPTBCL9CTNNB1 | |
| SCHEMBL9199740 | 0.78 | LMNA (0.44) | GAAMAPTKMT2AMEN1HPGD | |
| SCHEMBL6322393 | 0.77 | SMN1; SMN2 (0.64) | GAAMAPTBCL9CTNNB1KMT2A | |
| SCHEMBL21469741 | 0.77 | GAA (0.57) | RAB9AGAAMAPTBCL9CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0278454-B1 | 2,4- AND 2,5-PYRIDINE-DICARBOXYLIC-ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES BASED ON THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-01-27 | — | — | EP | disclosed |
| EP-0278454-A2 | 2,4- and 2,5-Pyridine-dicarboxylic-acid derivatives, process for their preparation, their use and medicines based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-17 | — | — | EP | disclosed |