Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | BAD | Q92934 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.32 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.32 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26013837 | 0.82 | GNG2 (0.33) | ALDH1A1HSD17B10HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL17237772 | 0.80 | HNF4A (0.39) | ALDH1A1HPGDMAPK1SMN1; SMN2MAPT | |
| SCHEMBL6874304 | 0.77 | MAPKAPK2 (0.35) | ALDH1A1HSD17B10BCL2L1HPGDBAD | |
| SCHEMBL29577247 | 0.75 | DRD2 (0.35) | ALDH1A1HSD17B10BCL2L1HPGDBAD | |
| SCHEMBL667761 | 0.73 | MAOA (0.45) | ALDH1A1HSD17B10HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL29438383 | 0.73 | MAOA (0.45) | ALDH1A1HSD17B10HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL311687 | 0.68 | MAOB (0.39) | BCL2L1MEN1MAPTKMT2ALMNA | |
| SCHEMBL6507292 | 0.68 | ALDH1A1 (0.48) | ALDH1A1HSD17B10BCL2L1HPGDBAD | |
| SCHEMBL9672093 | 0.67 | ABCC4 (0.34) | ALDH1A1HSD17B10HPGDSMN1; SMN2MAPT | |
| Biphenyl SCHEMBL15111097 | 0.65 | HDAC4 (0.45) | ALDH1A1HSD17B10BCL2L1HPGDHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0430693-B1 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS (JP) | 1995-05-31 | — | — | EP | disclosed |
| US-5114941-A | PYRIMIDINEDIONE DERIVATIVE COMPOUNDS, METHOD FOR PREPARING SAME, AND ANTIARRYTHMIC AGENTS CONTAINING SAME | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1992-05-19 | — | — | US | disclosed |
| EP-0430693-A2 | Pyrimidinedione derivative compounds, method for preparing same, and antiarrhythmic agents containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1991-06-05 | — | — | EP | disclosed |