SCHEMBL9201064

SCHEMBL9201064

COc1ccc(C2(Cn3cncn3)OCC2(C)C)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
MAPT P10636 2/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
HSP90AA1 P07900 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
CYP19A1 P11511 4/20 0.38
TSHR P16473 1/20 0.37
ALOX15 P16050 2/20 0.36
HPGD P15428 1/20 0.36
KDM4E B2RXH2 2/20 0.34
CHRNA1 P02708 1/20 0.34
CHRNG P07510 1/20 0.34
CHRNB1 P11230 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA4 P43681 1/20 0.34
CHRND Q07001 1/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9203098 0.86 HSP90AA1 (0.51) ALDH1A1MAPTSMN1; SMN2HSP90AA1NPSR1
SCHEMBL9201238 0.85 CYP3A4 (0.46) ALDH1A1SMN1; SMN2HSP90AA1NPSR1HPGD
SCHEMBL9198433 0.85 CYP3A4 (0.45) SMN1; SMN2HSP90AA1NPSR1CYP19A1LMNA
SCHEMBL9201249 0.83 HSP90AA1 (0.39) ALDH1A1MAPTSMN1; SMN2HSP90AA1NPSR1
SCHEMBL28608939 0.81 ALDH1A1 (0.47) ALDH1A1MAPTSMN1; SMN2HSP90AA1NPSR1
SCHEMBL9201247 0.80 ALDH1A1 (0.46) ALDH1A1MAPTSMN1; SMN2HSP90AA1NPSR1
SCHEMBL11541496 0.79 ALDH1A1 (0.50) ALDH1A1MAPTSMN1; SMN2HSP90AA1NPSR1
SCHEMBL9203493 0.78 ALDH1A1 (0.49) ALDH1A1MAPTSMN1; SMN2HSP90AA1NPSR1
SCHEMBL11542005 0.77 ALDH1A1 (0.48) ALDH1A1MAPTSMN1; SMN2HSP90AA1NPSR1
SCHEMBL28604608 0.75 HSP90AA1 (0.53) ALDH1A1MAPTSMN1; SMN2HSP90AA1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0431968-B1 Oxetane derivatives, their preparation and their use as anti-fungal or fungicidal agents SANKYO CO (JP) 1995-03-15 EP disclosed
US-5134152-A 1,2,4-Triazole compounds SANKYO COMPANY, LIMITED (JP) 1992-07-28 US disclosed
EP-0431968-A1 Oxetane derivatives, their preparation and their use as anti-fungal or fungicidal agents Sankyo Company Limited (JP) 1991-06-12 EP disclosed