SCHEMBL920140

SCHEMBL920140

COc1ccc(Oc2ccc(CNC(=O)c3ccc(F)nc3N)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 1/20 0.51
MAPT P10636 1/20 0.49
THRB P10828 1/20 0.49
HPGD P15428 6/20 0.48
ALDH1A1 P00352 1/20 0.48
CHRM4 P08173 3/20 0.47
FLT1 P17948 1/20 0.47
LRRK2 Q5S007 1/20 0.47
LMNA P02545 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
GAA P10253 1/20 0.47
ALOX15 P16050 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
KMT2A Q03164 1/20 0.47
LIPG Q9Y5X9 1/20 0.47
ADORA2A P29274 1/20 0.46
ADORA1 P30542 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL920524 0.92 KDM4E (0.50) EGLN1HPGDALDH1A1SMN1; SMN2KMT2A
SCHEMBL921095 0.91 LIPG (0.47) EGLN1MAPTHPGDSMN1; SMN2LIPG
SCHEMBL921316 0.91 MAPK14 (0.53) MAPTHPGDALDH1A1SMN1; SMN2KMT2A
SCHEMBL920506 0.91 CYP3A4 (0.54) MAPTTHRBLMNASMN1; SMN2L3MBTL1
SCHEMBL921469 0.89 MAPK14 (0.52) HPGDALDH1A1LMNASMN1; SMN2GAA
SCHEMBL922554 0.89 HPGD (0.55) MAPTHPGDALDH1A1CHRM4SMN1; SMN2
SCHEMBL919844 0.89 LIPG (0.45) EGLN1HPGDALDH1A1SMN1; SMN2LIPG
SCHEMBL921032 0.89 POLB (0.51) HPGDLMNASMN1; SMN2LIPG
SCHEMBL920472 0.88 LIPG (0.44) EGLN1MAPTTHRBHPGDLMNA
SCHEMBL921215 0.88 AKR1B1 (0.44) HPGDALDH1A1CHRM4KMT2ALIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed
WO-2009107764-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS 住友化学株式会社 (JP) 2009-09-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 EGLN1 430/4885MAPT 695/4885THRB 1345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.