Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MARS1 | P56192 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9200442 | 0.87 | PTGS2 (0.45) | ALDH1A1PTGS2MAPTPTGS1MARS1 | |
| SCHEMBL27694772 | 0.86 | MEN1 (0.47) | ALDH1A1PTGS2MAPTHTTPTGS1 | |
| SCHEMBL9208211 | 0.85 | CA9 (0.52) | ALDH1A1CA9MEN1KMT2AFAAH | |
| SCHEMBL9207624 | 0.82 | MARS1 (0.49) | ALDH1A1MAPTHTTMARS1MEN1 | |
| SCHEMBL9203885 | 0.82 | PTGS2 (0.47) | ALDH1A1PTGS2MAPTHTTPTGS1 | |
| SCHEMBL9201561 | 0.81 | CA9 (0.59) | ALDH1A1PTGS2MAPTPTGS1CA9 | |
| SCHEMBL9201489 | 0.80 | PTGS2 (0.41) | ALDH1A1PTGS2MAPTPTGS1MEN1 | |
| SCHEMBL9202142 | 0.77 | PTGS2 (0.52) | ALDH1A1PTGS2PTGS1MARS1MEN1 | |
| SCHEMBL27694770 | 0.76 | KMT2A (0.60) | ALDH1A1MAPTHTTMARS1MEN1 | |
| SCHEMBL9200861 | 0.75 | SCN9A (0.45) | ALDH1A1PTGS2PTGS1MARS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |