Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CCR6 | P51684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9278196 | 0.86 | PTGS2 (0.45) | PTGS2PTGS1MAPTRAB9AGAA | |
| SCHEMBL9204622 | 0.85 | PTGS2 (0.45) | PTGS2PTGS1KMT2A | |
| SCHEMBL9206528 | 0.81 | RXRA (0.40) | PTGS2PTGS1MAPTMEN1KMT2A | |
| SCHEMBL9207304 | 0.81 | PTGS2 (0.44) | PTGS2PTGS1MAPTMEN1KMT2A | |
| SCHEMBL9201550 | 0.80 | PTGS2 (0.49) | PTGS2PTGS1MAPTPOLBALDH1A1 | |
| SCHEMBL9201469 | 0.80 | ALDH1A1 (0.43) | PTGS2PTGS1MAPTMEN1KMT2A | |
| SCHEMBL9208211 | 0.76 | CA9 (0.52) | MEN1KMT2ASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL9202425 | 0.75 | PTGS2 (0.48) | PTGS2PTGS1NPC1RAB9A | |
| SCHEMBL9207196 | 0.73 | PTGS2 (0.46) | PTGS2PTGS1MAPTMEN1KMT2A | |
| SCHEMBL9201492 | 0.72 | PTGS2 (0.53) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |