SCHEMBL9201823

SCHEMBL9201823

Cc1noc(OC(=O)O)c1C(=O)NC(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.37
GAA P10253 2/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
HTT P42858 2/20 0.33
TSHR P16473 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
GABRA5 P31644 1/20 0.32
POLB P06746 1/20 0.32
GFER P55789 1/20 0.31
ALOX15 P16050 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9199743 0.78 HTT (0.48) ALDH1A1RAB9AHTTTSHRMEN1
SCHEMBL13101603 0.77 ALDH1A1 (0.51) ALDH1A1GAAHTTTSHRL3MBTL1
SCHEMBL9201816 0.76 GAA (0.37) ALDH1A1GAANPC1RAB9ASMN1; SMN2
SCHEMBL9526216 0.76 ALDH1A1 (0.37) ALDH1A1NPC1RAB9ASMN1; SMN2HTT
SCHEMBL9377323 0.75 HTT (0.43) ALDH1A1GAARAB9AHTTTSHR
SCHEMBL9240927 0.74 GAA (0.38) ALDH1A1GAANPC1RAB9ASMN1; SMN2
SCHEMBL9527107 0.72 TSHR (0.48) ALDH1A1GAANPC1RAB9ASMN1; SMN2
SCHEMBL9446181 0.71 HTT (0.44) ALDH1A1GAANPC1RAB9ASMN1; SMN2
SCHEMBL9203070 0.70 GABRA5 (0.38) ALDH1A1L3MBTL1GABRA5
SCHEMBL9446208 0.69 RAB9A (0.42) ALDH1A1GAANPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0418667-B1 Carboxylic acid amides BASF AG (DE) 1995-08-16 EP disclosed