SCHEMBL920269

SCHEMBL920269

Nc1ncccc1C(=O)NCc1ccc(Oc2cccc(F)c2)cc1

nearest known ligand 0.67

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MAPK8 P45983 1/20 0.53
KMT2A Q03164 1/20 0.50
HTR2C P28335 1/20 0.49
HTR2B P41595 1/20 0.49
KLKB1 P03952 1/20 0.48
LMNA P02545 1/20 0.47
HPGD P15428 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
PTGER4 P35408 1/20 0.46
PTGER2 P43116 1/20 0.46
PDPK1 O15530 1/20 0.46
CYP3A4 P08684 1/20 0.46
MAPK14 Q16539 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921259 0.93 KMT2A (0.53) MAPK8KMT2AKLKB1HPGD
SCHEMBL920343 0.90 KMT2A (0.61) MAPK8KMT2ALMNAHPGDSMN1; SMN2
SCHEMBL12352268 0.89 KMT2A (0.50) MAPK8KMT2ALMNAHPGDSMN1; SMN2
SCHEMBL920670 0.89 MAPK8 (0.53) MAPK8KMT2AHPGDCYP3A4MAPK14
SCHEMBL920461 0.88 MAPK8 (0.67) MAPK8KMT2ALMNAHPGDSMN1; SMN2
SCHEMBL921271 0.87 HPGD (0.57) MAPK8KMT2ALMNAHPGDSMN1; SMN2
SCHEMBL921448 0.87 MAPK8 (0.53) MAPK8KMT2ALMNAHPGDSMN1; SMN2
SCHEMBL920714 0.87 MAPK8 (0.53) MAPK8KMT2ALMNAHPGDSMN1; SMN2
SCHEMBL920462 0.87 MAPK8 (0.53) MAPK8KMT2ALMNAHPGDSMN1; SMN2
SCHEMBL920561 0.87 MAPK8 (0.53) MAPK8KLKB1LMNAHPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101951771-A Composition for agricultural use for controlling or preventing plant diseases caused by plant pathogens SUMITOMO CHEMICAL CO 2011-01-19 CN disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK8 2313/4885KMT2A 2469/4885HTR2C 4348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.