Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PELI1 | Q96FA3 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 8/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28839717 | 0.85 | BACE1 (0.56) | PELI1PTGS2MCL1ALOX5ESR2 | |
| SCHEMBL12042134 | 0.81 | HSD17B1 (0.43) | MCL1ESR1ESR2 | |
| SCHEMBL6068171 | 0.78 | ALOX5 (0.55) | PTGS2MCL1ALOX5WEE1ESR1 | |
| SCHEMBL6572402 | 0.78 | PDE10A (0.47) | PTGS2MCL1BACE1 | |
| SCHEMBL2770537 | 0.77 | PELI1 (0.57) | PELI1ALOX5ESR1ESR2ABL1 | |
| SCHEMBL10530044 | 0.77 | PTGS2 (0.62) | PTGS2ALOX5ESR1ESR2ABL1 | |
| Hydrochloric Acid SCHEMBL6780309 | 0.77 | PDE10A (0.46) | PTGS2MCL1BACE1 | |
| SCHEMBL4978057 | 0.75 | TRPA1 (0.48) | MCL1ALOX5BACE1 | |
| SCHEMBL16393890 | 0.74 | ALOX5 (0.65) | PELI1ALOX5ESR1ESR2ABL1 | |
| SCHEMBL9818839 | 0.74 | CA2 (0.50) | PTGS2MCL1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0382213-B1 | Biphenyl derivative, nerve cell degeneration repairing or protecting agent and process for preparing a phenyl derivative contained in the agent | OTSUKA PHARMA CO LTD (JP) | 1995-05-10 | — | — | EP | disclosed |
| US-5053548-A | Containing hydroxy substituents; nervous system disorders | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1991-10-01 | — | — | US | disclosed |