Sugi Predict

Sugi Predict / Compounds / SCHEMBL920782

SCHEMBL920782

SCHEMBL920782

Cc1cc(SC(=O)c2ccco2)c(C)o1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CES2 O00748 1/20 0.42
▸ CES1 P23141 1/20 0.42
▸ ALDH1A1 P00352 4/20 0.41
▸ POLB P06746 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ RECQL P46063 3/20 0.41
▸ TDP1 Q9NUW8 2/20 0.41
▸ MEN1 O00255 1/20 0.41
▸ THRB P10828 1/20 0.41
▸ APEX1 P27695 1/20 0.41
▸ HSD17B10 Q99714 3/20 0.39
▸ LMNA P02545 2/20 0.39
▸ ALOX15 P16050 2/20 0.39
▸ PTPN1 P18031 1/20 0.39
▸ SMN1; SMN2 Q16637 4/20 0.38
▸ NPC1 O15118 4/20 0.38
▸ RAB9A P51151 3/20 0.38
▸ TP53 P04637 2/20 0.38
▸ PKM P14618 2/20 0.38
▸ F12 P00748 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4572608 0.80 CES2 (0.46) CES2CES1ALDH1A1POLBKMT2A
SCHEMBL11849137 0.73 ALDH1A1 (0.58) CES2CES1ALDH1A1POLBKMT2A
SCHEMBL5499242 0.73 MAPT (0.41) ALDH1A1POLBKMT2AMEN1APEX1
SCHEMBL3507263 0.71 MAPT (0.40) ALDH1A1KMT2ARECQLMEN1LMNA
SCHEMBL3322705 0.69 — —
SCHEMBL3737300 0.65 — —
SCHEMBL30911231 0.65 CES2 (0.52) CES2CES1ALDH1A1POLBKMT2A
SCHEMBL9972664 0.65 CES2 (0.52) CES2CES1ALDH1A1POLBKMT2A
SCHEMBL5491831 0.65 MAPT (0.44) ALDH1A1LMNASMN1; SMN2NPC1RAB9A
SCHEMBL25320183 0.64 POLB (0.53) CES2CES1ALDH1A1POLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240108040-A1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2024-04-04 — — US disclosed
US-11758933-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2023-09-19 — — US disclosed
EP-3368542-B1 HIGH INTENSITY SWEETENERS FIRMENICH INCORPORATED (US) 2022-06-22 — — EP disclosed
US-11357246-B2 High intensity sweeteners FIRMENICH INCORPORATED (US) 2022-06-14 — — US disclosed
US-20210227863-A1 HIGH INTENSITY SWEETENERS SENOMYX, INC. 2021-07-29 — — US disclosed
EP-3356356-B1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 FIRMENICH INCORPORATED (US) 2021-05-26 — — EP disclosed
US-10392371-B2 Compounds useful as modulators of TRPM8 SENOMYX, INC. (US) 2019-08-27 — — US disclosed
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX, INC. 2019-06-13 — — US disclosed
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 SENOMYX INC (US) 2018-09-27 — — US disclosed
EP-3368542-A2 HIGH INTENSITY SWEETENERS Senomyx, Inc. (US) 2018-09-05 — — EP disclosed
EP-2451297-A2 FLAVORING COMPOSITIONS FOR SAVORY APPLICATIONS Firmenich S.A. (CH) 2012-05-16 — — EP disclosed
WO-2012054527-A2 CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES ELCELYX THERAPEUTICS, INC. (US) 2012-04-26 — — WO disclosed
US-20110020517-A1 TASTE MODIFYING PRODUCT FIRMENICH SA (CH) 2011-01-27 — — US disclosed
US-20110020518-A1 TASTE MODIFYING PRODUCT FIRMENICH SA (CH) 2011-01-27 — — US disclosed
EP-2273894-A1 TASTE MODIFYING PRODUCT Firmenich S.A. (CH) 2011-01-19 — — EP disclosed
WO-2011006080-A2 FLAVORING COMPOSITIONS FOR SAVORY APPLICATIONS FIRMENICH SA (CH) 2011-01-13 — — WO disclosed
US-20100310745-A1 FLAVORING COMPOSITIONS FOR SAVORY APPLICATIONS FIRMENICH SA (CH) 2010-12-09 — — US disclosed
EP-2200454-A1 FLAVORING COMPOSITIONS FOR SAVORY APPLICATIONS Firmenich S.A. (CH) 2010-06-30 — — EP disclosed
WO-2009122318-A1 TASTE MODIFYING PRODUCT FIRMENICH SA (CH) 2009-10-08 — — WO disclosed
WO-2009034528-A1 FLAVORING COMPOSITIONS FOR SAVORY APPLICATIONS FIRMENICH SA (CH) 2009-03-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240108040-A1 HIGH INTENSITY SWEETENERS TAS2R40, TAS2R60, TAS1R1 CES2 1537/4885CES1 2831/4885ALDH1A1 978/4885
US-10392371-B2 Compounds useful as modulators of TRPM8 TRPM8, TRPM4, TRPM6 CES2 2849/4885CES1 4061/4885ALDH1A1 3726/4885
US-11357246-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 CES2 1537/4885CES1 2831/4885ALDH1A1 978/4885
US-20190177308-A9 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 CES2 2352/4885CES1 3958/4885ALDH1A1 3880/4885
US-20180273517-A1 COMPOUNDS USEFUL AS MODULATORS OF TRPM8 TRPM8, TRPM6, TRPM4 CES2 2352/4885CES1 3958/4885ALDH1A1 3880/4885
US-20210227863-A1 HIGH INTENSITY SWEETENERS TAS2R40, TAS2R60, TAS1R1 CES2 1537/4885CES1 2831/4885ALDH1A1 978/4885
US-11758933-B2 High intensity sweeteners TAS2R40, TAS2R60, TAS1R1 CES2 1537/4885CES1 2831/4885ALDH1A1 978/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.