Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8904589 | 0.92 | ALDH1A1 (0.65) | SMN1; SMN2GAANOTUMKMT2AMAPT | |
| SCHEMBL5426108 | 0.87 | NOTUM (0.65) | SMN1; SMN2GAANOTUMKMT2AMAPT | |
| SCHEMBL10682774 | 0.82 | GAA (0.60) | SMN1; SMN2GAANOTUMKMT2AMAPT | |
| SCHEMBL10682781 | 0.82 | GAA (0.60) | SMN1; SMN2GAANOTUMKMT2AMAPT | |
| SCHEMBL9208129 | 0.82 | NOTUM (0.57) | SMN1; SMN2GAANOTUMKMT2AALDH1A1 | |
| SCHEMBL9278163 | 0.81 | SMN1; SMN2 (0.73) | SMN1; SMN2NOTUMKMT2AMAPTNPSR1 | |
| SCHEMBL1395834 | 0.78 | CHRM2 (0.58) | SMN1; SMN2GAAKMT2AMAPTMAPK1 | |
| SCHEMBL29554766 | 0.78 | NPC1 (0.71) | SMN1; SMN2NOTUMKMT2AMAPTNPSR1 | |
| SCHEMBL2116912 | 0.78 | NPC1 (0.71) | SMN1; SMN2NOTUMKMT2AMAPTNPSR1 | |
| SCHEMBL29520673 | 0.78 | NOTUM (0.69) | SMN1; SMN2GAANOTUMKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |