Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.41 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.41 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.41 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.41 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.41 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.41 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.41 |
| ▸ | FHIT | P49789 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9209066 | 1.00 | HTR2A (0.41) | HTR2ASLC6A4ADRB2HTR1ASLC6A2 | |
| SCHEMBL9209696 | 0.93 | HTR2A (0.47) | HTR2ASLC6A4ADRB2HTR1ASLC6A2 | |
| SCHEMBL9209645 | 0.83 | HTR2A (0.52) | HTR2ASLC6A4ADRB2HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL9212821 | 0.82 | HTR2A (0.51) | HTR2ASLC6A4ADRB2HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL9212810 | 0.82 | HTR2A (0.51) | HTR2ASLC6A4ADRB2HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL9213650 | 0.82 | HTR2A (0.51) | HTR2ASLC6A4ADRB2HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL9211654 | 0.79 | HTR2A (0.47) | HTR2ASLC6A4ADRB2HTR1ASLC6A2 | |
| SCHEMBL9214026 | 0.76 | KDM4E (0.52) | HTR2ASLC6A4ADRB2HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL9218819 | 0.75 | KDM4E (0.51) | HTR2ASLC6A4ADRB2HTR1ASLC6A2 | |
| SCHEMBL9214012 | 0.73 | KDM4E (0.45) | KDM4EALDH1A1HPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411912-B1 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | SANKYO CO (JP) | 1995-04-19 | — | — | EP | disclosed |
| EP-0411912-A2 | Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders | Sankyo Company Limited (JP) | 1991-02-06 | — | — | EP | disclosed |