Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 5/20 | 0.39 |
| ▸ | CES2 | O00748 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3754834 | 0.74 | KMT2A (0.56) | SMN1; SMN2CES1MAPK1LMNAL3MBTL1 | |
| SCHEMBL5995457 | 0.74 | MAOA (0.47) | SMN1; SMN2LMNAMAPTATMMEN1 | |
| SCHEMBL6362745 | 0.74 | L3MBTL1 (0.36) | CES1CES2MAPK1LMNAHTT | |
| SCHEMBL3298136 | 0.74 | CES1 (0.46) | SMN1; SMN2CES1CES2MAPK1LMNA | |
| SCHEMBL3287793 | 0.74 | CES1 (0.48) | SMN1; SMN2CES1CES2MAPK1LMNA | |
| SCHEMBL1254028 | 0.72 | CES1 (0.44) | SMN1; SMN2CES1CES2MAPK1LMNA | |
| SCHEMBL453359 | 0.72 | ATM (0.52) | SMN1; SMN2CES1CES2MAPK1LMNA | |
| SCHEMBL1874851 | 0.70 | ALDH1A1 (0.52) | SMN1; SMN2CES1CES2MAPK1LMNA | |
| SCHEMBL9804382 | 0.70 | CES1 (0.42) | SMN1; SMN2CES1CES2MAPK1LMNA | |
| SCHEMBL3281895 | 0.70 | L3MBTL1 (0.44) | SMN1; SMN2CES1CES2MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63216043-A | — | — | None | — | — | JP | disclosed |
| WO-1995009845-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |
| EP-0567223-A1 | Glutamic acid derivatives as antineoplastic agents | ELI LILLY AND COMPANY (US) | 1993-10-27 | — | — | EP | disclosed |
| US-5196424-A | Antitumor | ELI LILLY AND COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| JP-S63216043-A | PATTERN FORMING MATERIAL | NIPPON ZEON CO LTD | 1988-09-08 | — | — | JP | disclosed |