Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.37 |
| ▸ | EPOR | P19235 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8668465 | 0.83 | EGFR (0.37) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL7511627 | 0.83 | EGFR (0.37) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL28129661 | 0.79 | FOLH1 (0.47) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL28129663 | 0.79 | FOLH1 (0.47) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL1083608 | 0.76 | CPA3 (0.42) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL4775104 | 0.76 | CPA3 (0.42) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL28797503 | 0.76 | CPA3 (0.42) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL1083606 | 0.76 | CPA3 (0.42) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL31266570 | 0.76 | CPA3 (0.42) | ALDH1A1HPGDHSD17B10TDP1LMNA | |
| SCHEMBL11185212 | 0.75 | LMNA (0.41) | ALDH1A1HSD17B10TDP1LMNACPA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0667864-A1 | TRICYCLIC COMPOUNDS WITH PHARMACEUTICAL ACTIVITY. | ZENECA LTD (GB) | 1995-08-23 | — | — | EP | disclosed |
| WO-1994011354-A1 | TRICYCLIC COMPOUNDS WITH PHARMACEUTICAL ACTIVITY | ZENECA LIMITED (GB) | 1994-05-26 | — | — | WO | disclosed |
| US-4992550-A | Thymidylate synthetase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-02-12 | — | — | US | disclosed |