SCHEMBL920489

SCHEMBL920489

Nc1ncccc1C(=O)NCc1ccc(Oc2cc(F)cc(C(F)(F)F)c2)cc1

nearest known ligand 0.56

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 2/20 0.48
GPR52 Q9Y2T5 2/20 0.47
MAPK8 P45983 1/20 0.46
KMT2A Q03164 1/20 0.46
HDAC6 Q9UBN7 1/20 0.45
TLR8 Q9NR97 2/20 0.44
LMNA P02545 1/20 0.43
HPGD P15428 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL923196 0.91 GPR52 (0.49) MAPK14GPR52MAPK8KMT2AHPGD
SCHEMBL920722 0.89 MAPK14 (0.61) MAPK14MAPK8HDAC6LMNAHPGD
SCHEMBL920966 0.89 MAPK8 (0.46) MAPK14MAPK8KMT2AHDAC6LMNA
SCHEMBL919622 0.88 MAPK14 (0.54) MAPK14MAPK8KMT2AHDAC6
SCHEMBL920343 0.86 KMT2A (0.61) MAPK14MAPK8KMT2ALMNAHPGD
SCHEMBL921097 0.85 MAPK14 (0.47) MAPK14GPR52TLR8
SCHEMBL920269 0.85 MAPK8 (0.53) MAPK14MAPK8KMT2ALMNAHPGD
SCHEMBL921058 0.84 KCNQ3 (0.48) MAPK14MAPK8HDAC6
SCHEMBL920858 0.84 PPARG (0.47) MAPK14TLR8
SCHEMBL920958 0.84 MAPK14 (0.47) MAPK14MAPK8KMT2AHDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-01-13 US disclosed
EP-2248423-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS Sumitomo Chemical Company, Limited (JP) 2010-11-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110009454-A1 COMPOSITION FOR AGRICULTURAL USE FOR CONTROLLING OR PREVENTING PLANT DISEASES CAUSED BY PLANT PATHOGENS WIZ, TST, NAT1 MAPK14 905/4885GPR52 4701/4885MAPK8 2313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.