Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 3/20 | 0.45 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219499 | 0.82 | MCL1 (0.46) | ALDH1A1KDM4ETP53MAPTLMNA | |
| SCHEMBL9219766 | 0.81 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4ETP53SMN1; SMN2 | |
| SCHEMBL9216907 | 0.81 | ALDH1A1 (0.53) | ALDH1A1HPGDKDM4ETP53SMN1; SMN2 | |
| SCHEMBL9212149 | 0.81 | SCN2A (0.50) | ALDH1A1HPGDTP53SMN1; SMN2POLB | |
| SCHEMBL9211334 | 0.80 | TP53 (0.59) | ALDH1A1HPGDKDM4ETP53SMN1; SMN2 | |
| SCHEMBL9218881 | 0.79 | SMN1; SMN2 (0.55) | ALDH1A1HPGDTP53SMN1; SMN2POLB | |
| SCHEMBL9213625 | 0.77 | HPGD (0.46) | ALDH1A1HPGDTP53SMN1; SMN2LMNA | |
| SCHEMBL9216807 | 0.75 | ALDH1A1 (0.52) | ALDH1A1HPGDKDM4ETP53SMN1; SMN2 | |
| SCHEMBL9221111 | 0.74 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4ETP53SMN1; SMN2 | |
| SCHEMBL9217404 | 0.74 | SMN1; SMN2 (0.60) | ALDH1A1KDM4ETP53SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512570-B1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-10-11 | — | — | EP | disclosed |
| CN-1067886-A | New urea derivatives, their preparation method and pharmaceutical composition thereof | FUJISAWA PHARMACEUTICAL CO (JP) | 1993-01-13 | — | — | CN | disclosed |
| EP-0512570-A1 | Urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-11 | — | — | EP | disclosed |