Sugi Predict

Sugi Predict / Compounds / SCHEMBL921157

SCHEMBL921157

SCHEMBL921157

C[N]CCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HIF1A Q16665 3/20 0.52
▸ CYP2A6 P11509 2/20 0.52
▸ MIF P14174 2/20 0.52
▸ TRPA1 O75762 1/20 0.52
▸ CYP2E1 P05181 1/20 0.52
▸ CYP2A13 Q16696 1/20 0.52
▸ EPAS1 Q99814 1/20 0.52
▸ ALDH1A1 P00352 1/20 0.48
▸ HPGD P15428 1/20 0.48
▸ ALOX15 P16050 1/20 0.48
▸ ALOX12 P18054 1/20 0.48
▸ CASP1 P29466 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ GRIN1 Q05586 1/20 0.47
▸ GRIN2B Q13224 1/20 0.47
▸ TAAR1 Q96RJ0 3/20 0.46
▸ ATM Q13315 1/20 0.46
▸ TDP1 Q9NUW8 3/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ HTR2A P28223 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL919176 0.85 HTR3A (0.57) MIFHTR3A
SCHEMBL919488 0.83 MIF (0.57) MIFHTR3A
SCHEMBL5911061 0.81 NAAA (0.58) MIFHTR3AMAPT
SCHEMBL920069 0.81 NAAA (0.58) MIFHTR3AMAPT
SCHEMBL8837167 0.80 HIF1A (0.48) HIF1ACYP2A6MIFTRPA1CYP2E1
SCHEMBL8837171 0.80 HIF1A (0.48) HIF1ACYP2A6MIFTRPA1CYP2E1
SCHEMBL7484724 0.79 HIF1A (0.52) HIF1ACYP2A6MIFTRPA1CYP2E1
SCHEMBL6335562 0.78 HIF1A (0.56) HIF1ACYP2A6MIFTRPA1CYP2E1
SCHEMBL721250 0.78 HIF1A (0.56) HIF1ACYP2A6MIFTRPA1CYP2E1
SCHEMBL11267260 0.77 HTR3E (0.57) CYP2A6MIFALDH1A1ALOX15TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 260 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110218206-B Bisindolylmaleimide derivative and preparation method and application thereof 中国海洋大学 2022-03-04 — — CN claimed
US-9198426-B2 Use of 5 pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-12-01 — — US claimed
EP-2090571-B1 Pyrimidine derivates, medicaments comprising them, their use and process of their preparation BOEHRINGER INGELHEIM PHARMA (DE) 2012-05-16 — — EP claimed
EP-2378880-A1 USE OF 5-PYRIDIN-4YL(1,3)THIAZOLE FOR TREATING PHYTOPATHOGENIC FUNGI BAYER CROPSCIENCE AG (DE) 2011-10-26 — — EP claimed
US-20100168185-A1 Use of 5-pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi BAYER CORPSCIENCE AG (DE) 2010-07-01 — — US claimed
WO-2010069494-A1 USE OF 5-PYRIDIN-4YL(1,3)THIAZOLE FOR TREATING PHYTOPATHOGENIC FUNGI BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2010-06-24 — — WO claimed
EP-2198710-A1 Use of 5-pyridin-4yl-(1,3) thiazoles for combating phytopathogenic fungi Bayer CropScience AG (DE) 2010-06-23 — — EP claimed
US-7709480-B2 Pyrimidine derivatives BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2010-05-04 — — US claimed
US-20090048295-A1 SUBSTITUTED 5,6,7,8-TETRAHYDROQUINOLINE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE THEREOF JANSSEN PHARMACEUTICE N.V. (BE) 2009-02-19 — — US claimed
EP-2024359-A1 COMPOUNDS THAT ARE AGONISTS OF MUSCARINIC RECEPTORS AND THAT MAY BE EFFECTIVE IN TREATING PAIN, ALZHEIMER'S DECEASE AND/OR SCHIZOPHRENIA AstraZeneca AB (SE) 2009-02-18 — — EP claimed
EP-0411333-B1 Antiherpes tetrapeptide derivatives having a substituted aspartic acid side chain BIO MEGA BOEHRINGER INGELHEIM (CA) 1995-05-31 — — EP claimed
EP-0461546-B1 Antiherpes peptide derivatives having a 1,4-dioxo-C4 N-terminus BIO MEGA BOEHRINGER INGELHEIM (CA) 1995-03-22 — — EP claimed
EP-0411334-B1 Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain BIO MEGA BOEHRINGER INGELHEIM (CA) 1995-02-22 — — EP claimed
US-5378803-A Analgesics, substance P antagonists, peptides containing thiazole, oxazole or imidazole ring and indole ring STERLING WINTHROP INC. (US) 1995-01-03 — — US claimed
EP-0600834-A1 Use of methanebisphosphonic acid derivatives for the manufacture of a medicament for fracture healing CIBA-GEIGY AG (CH) 1994-06-08 — — EP claimed
EP-0374054-B1 INDANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES OBTAINED, THEIR USE AS MEDICINES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1993-10-06 — — EP claimed
EP-0550385-A1 Oral pharmaceutical compositions containing derivatives of methane-diphosphonic acid and 18-crown-6 ethers CIBA-GEIGY AG (CH) 1993-07-07 — — EP claimed
EP-0461546-A2 Antiherpes peptide derivatives having a 1,4-dioxo-C4 N-terminus BIO-MEGA/BOEHRINGER INGELHEIM RESEARCH INC. (CA) 1991-12-18 — — EP claimed
EP-0208404-A2 Benzothiazine dioxide derivatives PFIZER INC. (US) 1987-01-14 — — EP claimed
US-4623486-A [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity PFIZER INC. (US) 1986-11-18 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100168185-A1 Use of 5-pyridin-4-yl-1,3-thiazoles for controlling phytopathogenic fungi PIR, PNPO, PDXK HIF1A 4359/4885CYP2A6 2384/4885MIF 2458/4885
US-20090048295-A1 SUBSTITUTED 5,6,7,8-TETRAHYDROQUINOLINE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE THEREOF C3AR1, C5AR1, C5AR2 HIF1A 2289/4885CYP2A6 852/4885MIF 272/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.