Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216056 | 0.92 | BCHE (0.44) | GAACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9212603 | 0.92 | GAA (0.50) | GAAMEN1KMT2ANPC1RAB9A | |
| SCHEMBL9208083 | 0.91 | ABCB1 (0.44) | GAACHRNB2CHRNB4CHRNA3CHRNA4 | |
| Hydrochloric Acid SCHEMBL9212998 | 0.90 | ABCB1 (0.44) | GAACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9207120 | 0.89 | ACHE (0.47) | GAACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9213519 | 0.88 | GAA (0.40) | GAACHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9212457 | 0.88 | ABCB1 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL9212951 | 0.88 | ABCB1 (0.47) | — | |
| SCHEMBL9215835 | 0.88 | SIGMAR1 (0.46) | GAAMEN1KMT2A | |
| SCHEMBL9213241 | 0.87 | LTA4H (0.52) | GAACHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292840-B1 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | THOMAE GMBH DR K (DE) | 1995-08-09 | — | — | EP | disclosed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0292840-A2 | Cyclic amine derivatives, medicaments containing these compounds and procedure for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-11-30 | — | — | EP | disclosed |