SCHEMBL9212581

SCHEMBL9212581

COc1ccc2c(c1)=c1cc3c(c(C)c1N=2)=C(C)C(C(=O)OCc1ccccc1)=N3

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 2/20 0.38
CASP3 P42574 1/20 0.38
KMT2A Q03164 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
PRNP P04156 1/20 0.37
TP53 P04637 1/20 0.36
POLB P06746 1/20 0.36
AURKA O14965 1/20 0.36
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MAPT P10636 1/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
ADORA2A P29274 1/20 0.36
ADORA2B P29275 1/20 0.36
ADORA1 P30542 1/20 0.36
NPC1 O15118 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1388443 0.88 DHODH (0.38) DHODHKMT2ATDP1POLBKDM4E
SCHEMBL9434825 0.88 DHODH (0.38) DHODHKMT2ATDP1POLBALDH1A1
SCHEMBL1388453 0.80 TDP1 (0.35) KMT2ATDP1POLBALDH1A1KDM4E
SCHEMBL9434910 0.76 HRH3 (0.37) ALDH1A1KDM4EMAPTMAOANPC1
SCHEMBL9434110 0.73 SMN1; SMN2 (0.36) TDP1POLBALDH1A1KDM4EMAPT
SCHEMBL7966221 0.72 TDP1 (0.38) KMT2ATDP1POLBALDH1A1MAPT
SCHEMBL8911745 0.72 MAPT (0.36) DHODHKMT2ATDP1POLBALDH1A1
SCHEMBL1388444 0.68 FGB (0.38) KMT2ATDP1POLBALDH1A1KDM4E
SCHEMBL8363373 0.67 TDP1 (0.38) KMT2ATDP1POLBALDH1A1MAPT
SCHEMBL25633560 0.67 DHODH (0.54) DHODHCASP3KMT2ASENP8SENP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0651750-A1 TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS THE WELLCOME FOUNDATION LIMITED (GB) 1995-05-10 EP disclosed
WO-1994002483-A1 TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS THE WELLCOME FOUNDATION LIMITED (GB) 1994-02-03 WO disclosed