Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388443 | 0.89 | DHODH (0.38) | DHODHPOLBKMT2ANPSR1L3MBTL1 | |
| SCHEMBL9212581 | 0.88 | DHODH (0.38) | DHODHPOLBKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL1388453 | 0.80 | TDP1 (0.35) | POLBKMT2ANPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL9434910 | 0.77 | HRH3 (0.37) | L3MBTL1ALDH1A1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL9434110 | 0.73 | SMN1; SMN2 (0.36) | POLBNPSR1L3MBTL1ALDH1A1HTT | |
| SCHEMBL7966221 | 0.73 | TDP1 (0.38) | POLBKMT2ANPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL8911745 | 0.72 | MAPT (0.36) | DHODHGPBAR1POLBKMT2ANPSR1 | |
| SCHEMBL1388444 | 0.68 | FGB (0.38) | POLBKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL8363373 | 0.68 | TDP1 (0.38) | POLBKMT2ANPSR1L3MBTL1ALDH1A1 | |
| SCHEMBL20831012 | 0.67 | ALDH1A1 (0.55) | DHODHGPBAR1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |