Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | HTR1A | P08908 | 6/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9211546 | 0.90 | HTR2A (0.64) | HTR1ADRD2DRD4DRD3HTR2A | |
| SCHEMBL9214152 | 0.90 | HTR1A (0.65) | KCNH2HTR6HTR1AHTR7SLC6A4 | |
| SCHEMBL9205321 | 0.88 | DRD2 (0.52) | KCNH2HTR6HTR1AHTR7SLC6A4 | |
| SCHEMBL9205349 | 0.87 | ABCC1 (0.57) | KCNH2HTR6HTR1AHTR7SLC6A4 | |
| SCHEMBL9205705 | 0.84 | HTR1A (0.73) | KCNH2HTR6HTR1AHTR7SLC6A4 | |
| SCHEMBL9274974 | 0.84 | DRD2 (0.57) | HTR1ADRD2DRD4DRD3HTR2A | |
| SCHEMBL9210187 | 0.82 | HTR1A (0.64) | KCNH2HTR6HTR1AHTR7SLC6A4 | |
| SCHEMBL9210900 | 0.81 | HTR1A (0.65) | KCNH2HTR6HTR1AHTR7SLC6A4 | |
| SCHEMBL6354737 | 0.81 | HTR1A (0.66) | KCNH2HTR6HTR1AHTR7SLC6A4 | |
| SCHEMBL27989611 | 0.81 | HTR1A (0.69) | KCNH2HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0345808-B1 | 1-Indolylalkyl-4-(substituted-pyridinyl)piperazines | BRISTOL MYERS SQUIBB CO (US) | 1995-01-11 | — | — | EP | claimed |
| US-4954502-A | Antidepressants | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-09-04 | — | — | US | claimed |