Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9220456 | 0.81 | IDO1 (0.37) | MEN1KMT2ANPC1RAB9AHSD17B10 | |
| SCHEMBL8992831 | 0.79 | LTA4H (0.42) | MEN1KMT2ANPC1RAB9ACYP1A2 | |
| SCHEMBL9219353 | 0.78 | MAPT (0.56) | MEN1KMT2ANPC1RAB9ASRC | |
| SCHEMBL9215058 | 0.78 | GPR119 (0.40) | MEN1KMT2ANPC1RAB9ACYP1A2 | |
| SCHEMBL9219409 | 0.78 | SMPD3 (0.41) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL9220988 | 0.76 | MAPT (0.45) | MEN1KMT2ANPC1RAB9ASRC | |
| SCHEMBL9218703 | 0.76 | MAPT (0.48) | MEN1KMT2ANPC1RAB9ASRC | |
| SCHEMBL9172768 | 0.76 | RAB9A (0.55) | MEN1KMT2ANPC1RAB9AHSD17B10 | |
| SCHEMBL9217924 | 0.76 | KMT2A (0.54) | MEN1KMT2ANPC1RAB9ASRC | |
| SCHEMBL9172328 | 0.75 | FYN (0.40) | MEN1KMT2ANPC1RAB9ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |