Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 8/20 | 0.46 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | ABL2 | P42684 | 5/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215969 | 0.87 | CYP1A1 (0.42) | KDRTGFBR2ABL1LMNAMAPT | |
| SCHEMBL9212121 | 0.86 | KDR (0.44) | KDRSRCABL1EGFRABL2 | |
| SCHEMBL9280278 | 0.85 | ALDH1A1 (0.44) | KDRSRCKDM4EALDH1A1LMNA | |
| SCHEMBL8992950 | 0.84 | LTA4H (0.43) | TGFBR2SRCABL1EGFRABL2 | |
| SCHEMBL9217924 | 0.84 | KMT2A (0.54) | KDRTGFBR2SRCABL1EGFR | |
| SCHEMBL8992882 | 0.83 | HCAR2 (0.46) | SRCCDK1CYP3A4CYP2D6MAPT | |
| SCHEMBL9221803 | 0.83 | ALDH1A1 (0.44) | KDRSRCKDM4EALDH1A1MAPT | |
| SCHEMBL9218534 | 0.82 | SRC (0.47) | KDRSRCABL1EGFRABL2 | |
| SCHEMBL8992845 | 0.82 | FYN (0.40) | KDRTGFBR2SRCABL1EGFR | |
| SCHEMBL9173974 | 0.82 | KDR (0.38) | KDRTGFBR2EGLN2SRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7118272-A | — | — | None | — | — | JP | disclosed |
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| JP-H07118272-A | PRODUCTION OF 4-HYDROXYPYRAZOLOTRIAZINE DERIVATIVE AND ITS OPTICALLY ACTIVE SUBSTANCE | OTSUKA PHARMACEUT CO LTD | 1995-05-09 | — | — | JP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |