Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | HCK | P08631 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PRKDC | P78527 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ABL2 | P42684 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | NPM1 | P06748 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | LYN | P07948 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9219234 | 0.86 | NPC1 (0.57) | SRCKDRABL1EGFRABL2 | |
| SCHEMBL9212913 | 0.86 | EGLN2 (0.43) | SRCKDRLCKHCKMEN1 | |
| SCHEMBL9221803 | 0.86 | ALDH1A1 (0.44) | SRCKDRLCKHCKMEN1 | |
| SCHEMBL9172768 | 0.84 | RAB9A (0.55) | KDRMEN1NPC1RAB9AKMT2A | |
| SCHEMBL9214289 | 0.82 | KDR (0.50) | SRCKDRABL1EGFRABL2 | |
| SCHEMBL9216208 | 0.82 | SMN1; SMN2 (0.40) | SRCKDRLCKHCKNTRK1 | |
| SCHEMBL9215756 | 0.81 | SRC (0.45) | SRCKDRLCKHCKABL1 | |
| SCHEMBL9212121 | 0.81 | KDR (0.44) | SRCKDRLCKPIK3CGPIK3CD | |
| SCHEMBL9221859 | 0.81 | CYP17A1 (0.45) | SRCKDRHCKPIK3CGPIK3CD | |
| SCHEMBL9221094 | 0.80 | MAPT (0.43) | PIK3CGPIK3CDPIK3CAPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0269859-B2 | Pyrazolotriazine compounds | OTSUKA PHARMA CO LTD (JP) | 1995-10-18 | — | — | EP | disclosed |
| US-4824834-A | TREATING GOUT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1989-04-25 | — | — | US | disclosed |
| EP-0269859-A2 | Pyrazolotriazine compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |