Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | PRKACA | P17612 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | PRKX | P51817 | 3/20 | 0.39 |
| ▸ | PRKCG | P05129 | 2/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993053 | 0.85 | HCAR2 (0.42) | HCAR2MAPK1NPC1RAB9AKMT2A | |
| SCHEMBL9214289 | 0.83 | KDR (0.50) | CLK4CDK1RPS6KA3DYRK1ACYP3A4 | |
| SCHEMBL9217924 | 0.81 | KMT2A (0.54) | HCAR2MAPK1NPC1RAB9AKMT2A | |
| SCHEMBL8992950 | 0.80 | LTA4H (0.43) | HCAR2MAPK1CLK4CDK1NPC1 | |
| SCHEMBL9215969 | 0.76 | CYP1A1 (0.42) | HCAR2MAPK1NPC1RAB9AKMT2A | |
| SCHEMBL8992990 | 0.74 | KMT2A (0.48) | HCAR2MAPK1NPC1RAB9AKMT2A | |
| SCHEMBL8993032 | 0.74 | DHFR (0.40) | HCAR2MAPK1CLK4CDK1NPC1 | |
| SCHEMBL8992845 | 0.74 | FYN (0.40) | HCAR2CLK4CDK1KMT2ACYP3A4 | |
| SCHEMBL9173974 | 0.74 | KDR (0.38) | HCAR2MAPK1CDK1NPC1RAB9A | |
| SCHEMBL8993148 | 0.74 | KMT2A (0.41) | HCAR2MAPK1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516777-A | PROSTATE CANCER THERAPY | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-05-14 | — | — | US | disclosed |
| US-5409928-A | Prostate diseases, alopecia | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-25 | — | — | US | disclosed |
| EP-0594149-A2 | Condensed pyrazole derivatives, method of manufacturing the same, and androgen inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-27 | — | — | EP | disclosed |